Results 161 to 170 of about 413,811 (335)
Interpretation of RNA Universe and Coding Potential Using IntRNA
Advanced Science, EarlyView.This study constructs a multi‐channel deep learning framework IntRNA to interpret RNA universe and coding potential. IntRNA consistently performed the best among existing methods in various benchmarks. Moreover, IntRNA’s interpretability is also validated by real‐world analysis, which found some features indicating long‐distance contact between ...
Yunxia Wang +8 more
wiley +1 more source
Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome
Advanced Science, EarlyView.This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha +11 more
wiley +1 more source
Intron length polymorphism of actin genes in different varieties of ukrainian selection flax
, 1970 A. S. Postovoitovа +3 more
openalex +2 more sources
On the Estimation of Intron Evolution
PLoS Computational Biology, 2006 PLoS Computational Biology recently published an article about spliceosomal intron evolution by Nguyen, Yoshihama, and Kenmochi [1]. The authors were unaware of some earlier independent results. Foremostly, the main point of the article—that of estimating the density of potential intron sites—is not novel.
openaire +4 more sources
Advanced Science, EarlyView.CircSMPD4 physically combines with lactate dehydrogenase A (LDHA) and reduces its acetylation level via SIRT2‐dependent deacetylation, thereby inhibiting chaperone‐mediated autophagy‐lysosome degradation of LDHA. Upregulating LDHA leads to increasing lactate production and extracellular export, which in turn suppresses natural killer cell cytotoxicity ...
Hao Shen +16 more
wiley +1 more source
Variation of tRNA modifications with and without intron dependency
Frontiers in GeneticstRNAs have recently gained attention for their novel regulatory roles in translation and for their diverse functions beyond translation. One of the most remarkable aspects of tRNA biogenesis is the incorporation of various chemical modifications, ranging
Sachiko Hayashi
doaj +1 more source
A novel role for the 3' region of introns in pre-mRNA splicing of Saccharomyces cerevisiae. [PDF]
, 1987 Brian C. Rymond +2 more
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Laeverin is Cell‐Surface Target for Liquid‐Phase Metastasizing Cancer Cells
Advanced Science, EarlyView.This study revealed that epithelial cancer cells in the floating phase induce the expression of laeverin (LVRN) that is a trophoblast‐specific and cell‐surface immunoregulatory factor and showed that anti‐LVRN ADC is a promising agent that can attack cancer cells in the metastatic liquid phase and block further distant metastasis.
Haruki Kasama +17 more
wiley +1 more source
Kluyveromyces lactis maintains Saccharomyces cerevisiae intron-encoded splicing signals. [PDF]
, 1989 James O. Deshler, G P Larson, J J Rossi
openalex +1 more source