Results 181 to 190 of about 416,899 (328)

Detection and evaluation of intron retention events in the human transcriptome [PDF]

, 2004
Pedro A. F. Galante, Noboru J. Sakabe, Natanja Kirschbaum-Slager, Sandro J. de Souza   +3 more
openalex   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Alu Overexpression Leads to an Increased Double‐Stranded RNA Signature in Dermatomyositis

Arthritis &Rheumatology, EarlyView.
Objective Dermatomyositis is an autoimmune condition characterized by a high interferon signature of unknown etiology. Because coding sequences constitute <1.2% of our genomes, there is a need to explore the role of the noncoding genome in disease pathogenesis.
Rayan Najjar, Andrew Mammen, Tomas Mustelin   +2 more
wiley   +1 more source

Reduced Cas9 transgene silencing by incorporation of intron sequences. [PDF]

Nat Commun
Arana S, Du PP, Vaughan-Jackson A, Enright N, Spees K, Valbuena R, Garcia CA, Nguyen T, Venida A, Seczynska M, Bintu L, Lehner PJ, Prolo LM, Bassik MC.   +13 more
europepmc   +1 more source

The INSPECTOR study: enhanced feasibility for clinical translation of a multi‐cancer early detection method based on enzyme‐assisted high signal‐to‐noise ratio sequencing of methylated circulating tumor DNA

Cancer Communications, EarlyView.
Abstract Background Blood‐based cell‐free DNA (cfDNA) methylation testing has emerged as a promising approach for multi‐cancer early detection (MCED), holding the potential to improve cancer survival rates. However, traditional bisulfite‐based methods often encounter sensitivity limitations in detecting early‐stage malignancies or certain cancer types.
Hui‐Yan Luo, Wei Wei, Pansong Li, Qi‐Hua Zhang, Zhipeng Zhou, Liang Cui, Yong‐Bin Lin, Hong Yang, Xianyu Zhong, Qingfeng Liu, Han Yang, Kong‐Jia Luo, Hai‐Bo Qiu, Shu‐Qiang Yuan, Yuan‐Fang Li, Zhi‐Wei Zhou, Xiao‐Jun Lin, Bo‐Kang Cui, Rong‐Xin Zhang, Wen‐Hua Fan, He Huang, Chun‐Yan Lan, Jun‐Dong Li, Zhi‐Qiang Wang, Bin‐Kui Li, Rong‐Ping Guo, Jun Tang, Xin Huang, Mian Xi, Yuying Liu, Chuanbo Xie, Shi Chen, Zhi‐Hu Li, Yu‐Hua Liu, Xiao‐Ting Zhang, Qiang Zeng, Xin Yi, Rui‐Hua Xu   +37 more
wiley   +1 more source

Impact of U2-type introns on splice site prediction in A. thaliana species using deep learning. [PDF]

BMC Bioinformatics
Kabanga E, Jee S, Yun S, Depuydt S, Van Messem A, De Neve W.   +5 more
europepmc   +1 more source

Intron-Size Constraint as a Mutational Mechanism in Rothmund-Thomson Syndrome [PDF]

, 2002
Lisa L. Wang, Kim C. Worley, Anu Gannavarapu, Murali Chintagumpala, Moise L. Levy, Sharon E. Plon   +5 more
openalex   +1 more source

Enhancing G‐Quadruplex Binding: Rational Design and Biophysical Evaluation of Dimeric Ligands

Chemistry – A European Journal, EarlyView.
Fluorescence thermal shift assays, electrospray ionization‐mass spectrometry, CD spectroscopy, molecular modeling and cytotoxicity assays were enrolled to study the binding of a rationally designed anthraquinone‐based G‐quadruplex binder interacting with the nucleic acid as a molecular tweezer.
Matteo Giannangeli, Nicolò Dal Ponte, Margrate Anyanwu, Martina Brigida Romanello, Ernesto Mucenji, Riccardo Rigo, Giovanni Ribaudo, Claudia Sissi, Alessandra Gianoncelli   +8 more
wiley   +1 more source

A specialized bacterial group II intron is a highly efficient retrotransposon. [PDF]

Mob DNA
Gomes L, Toffano-Nioche C, Gautheret D, Costa M.   +3 more
europepmc   +1 more source

In silico characterisation and chromosomal localisation of human RRH (peropsin) – implications for opsin evolution [PDF]

, 2003
Bellingham, J, Foster, R G, Wells, D J
core   +1 more source