Results 201 to 210 of about 232,441 (272)

Improved Prediction of CYP2D6 Catalyzed Drug Metabolism by Taking Variant Substrate Specificities and Novel Polymorphic Haplotypes into Account

Clinical Pharmacology &Therapeutics, EarlyView.
The polymorphic CYP2D6 enzyme plays a pivotal role in the metabolism of approximately 25% of clinically prescribed drugs. However, the impact of specific genetic variants on the interindividual variability in CYP2D6‐mediated drug metabolism remains insufficiently quantified. This translational study sought to address this gap by analyzing the genotypes
Inger Johansson, Emmanouella M. Xanthopoulou, Yitian Zhou, Anabel Sanchez‐Spitman, Maaike van der Lee, Birgit M. Wollmann, Elisabet Størset, Jesse J. Swen, Henk‐Jan Guchelaar, Espen Molden, Marin M. Jukic, Magnus Ingelman‐Sundberg   +11 more
wiley   +1 more source

Direct repeats found in the vicinity of intron splice sites. [PDF]

Naturwissenschaften
Rogers SO, Bendich AJ.
europepmc   +1 more source

G/A polymorphism in an intron of the fibrillin gene FBNI [PDF]

, 1991
D. Hewett, Jennifer Lynch, Maurice Godfrey, Bryan Sykes   +3 more
openalex   +1 more source

Enigmatic Nodal and Lefty gene repertoire discrepancy: Latent evolutionary history revealed by vertebrate‐wide phylogeny

Developmental Dynamics, EarlyView.
Abstract Homology in vertebrate body plans is traditionally ascribed to the high‐level conservation of regulatory components within the genetic programs governing them, particularly during the “phylotypic stage.” However, advancements in embryology and molecular phylogeny have unveiled the dynamic nature of gene repertoires responsible for early ...
Shigehiro Kuraku
wiley   +1 more source

A novel MoClo-mediated intron insertion system facilitates enhanced transgene expression in <i>Chlamydomonas reinhardtii</i>. [PDF]

Front Plant Sci
Aschern M, Braad J, Milito A, Alzuria D, Yang JS.   +4 more
europepmc   +1 more source

Expression from herpesvirus promoters does not relieve the intron requirement for cytoplasmic accumulation of human β-globin mRNA [PDF]

, 1991
Xian-ming Yu, Gregory Gelembiuk, Chung-Yu Wang, Wang‐Shick Ryu, Janet E. Mertz   +4 more
openalex   +1 more source

Elp1 function in placode‐derived neurons is critical for proper trigeminal ganglion development

Developmental Dynamics, EarlyView.
Abstract Background The trigeminal nerve is the largest cranial nerve and functions in somatosensation. Cell bodies of this nerve are positioned in the trigeminal ganglion, which arises from the coalescence of neural crest and placode cells. While this dual cellular origin has been known for decades, the molecular mechanisms controlling trigeminal ...
Margaret A. Hines, Lisa A. Taneyhill
wiley   +1 more source

Mutations of the brassinosteroid biosynthesis gene HvDWARF5 enable balance between semi-dwarfism and maintenance of grain size in barley. [PDF]

Physiol Plant
Zolkiewicz K, Oklestkova J, Chmielewska B, Gruszka D.   +3 more
europepmc   +1 more source

Different exon-intron organization at the 5' part of a mouse class I gene is used to generate a novel H-2Kd-related mRNA.

, 1983
Jean‐Louis Lalanne, Madeleine Cochet, Arthur Kümmer, Gabriel Gachelin, Philippe Kourilsky   +4 more
openalex   +1 more source

The second intron of the K-ras gene containsregulatory elements associated with mouse lung tumorsusceptibility. [PDF]

, 1994
Bin Chen, Lennart Johanson, Jonathan S. Wiest, M W Anderson, Ming You   +4 more
openalex   +1 more source