Results 201 to 210 of about 416,899 (328)

Characterization of the genes encoding phycoerythrin in the red alga Rhodella violacea: evidence for a splitting of the rpeB gene by an intron.

, 1992
Cécile Bernard, J. Thomas, Didier Mazel, A. Mousseau, Marie Castets, Nicole Tandeau de Marsac, J.P. Dubacq   +6 more
openalex   +2 more sources

PCR with end trimming and cassette ligation: a rapid method to clone exon-intron boundaries and a 5'-upstream sequence of genomic DNA based on a cDNA sequence. [PDF]

, 1994
Hiroyuki Iwahana, Toshiyuki Tsujisawa, Rumi Katashima, Katsuhiko Yoshimoto, Makoto Itakura   +4 more
openalex   +1 more source

Effects of High‐ and Low‐Fat Meals on the Bioavailability and Pharmacokinetics of Votoplam, a HTT Gene Splicing Modifier

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Votoplam is a novel, orally bioavailable, small molecule HTT gene splicing modifier that is being developed for the treatment of Huntington's disease. This was a single dose, open‐label, two‐period, crossover food effect study that evaluated the effect of high‐ and low‐fat meals on 20 mg votoplam in healthy participants. There was a washout of
Lucy Lee, Amy‐Lee Richards, Nageswara Reddy, Brian Beers, Lee Golden, Ronald Kong   +5 more
wiley   +1 more source

Detection of leukemia gene fusions on DNA-level through targeted Next-Generation Sequencing. [PDF]

PLoS One
Chen B, Gao Z, Chen L, Zhang H, Lin Y, Li J.   +5 more
europepmc   +1 more source

Control of mRNA Stability in Fungi by NMD, EJC and CBC Factors Through 3′UTR Introns [PDF]

, 2015
Ying Zhang, Matthew S. Sachs
openalex   +1 more source

Drug Repositioning of Pegbing® for Essential Thrombocythemia: Insights from PK/PD Modeling and Extrapolation

Clinical Pharmacology &Therapeutics, EarlyView.
Pegbing® (peginterferon alfa‐2b), a pegylated interferon‐alpha, is approved for the treatment of chronic hepatitis B (CHB) and C. One of its adverse effects is platelet (PLT) suppression. It is currently being repurposed for the treatment of essential thrombocythemia (ET), a rare myeloproliferative disorder characterized by abnormally elevated PLT ...
Weizhe Jian, Yalin Yin, Rong Chen, Junsheng Xue, Jianbo Gu, Zhengfang Du, Ruoyi He, Tianyan Zhou   +7 more
wiley   +1 more source

Mechanistic study of <i>TFE3</i> breakage in <i>TFE3</i>-rearranged renal cell carcinoma: the perspective of non-canonical DNA structures and their stability. [PDF]

Front Genet
Zhang X, Dang Q, Pan X, Deng Z, Xu Y, Gan W, Guo H.   +6 more
europepmc   +1 more source

Three different group I introns in the nuclear large subunit ribosomal DNA of the amoeboflagellate Naegleria

, 1998
Johan F. De Jonckheere, S. Brown
openalex   +2 more sources

Spread of the group II intron RmInt1 and its insertion sequence target sites in the plant endosymbiontSinorhizobium meliloti [PDF]

, 2011
Emanuele G. Biondi, Nicolás Toro, Marco Bazzicalupo, Francisco Martı́nez-Abarca   +3 more
openalex   +1 more source

Pathway‐Informed Machine Learning Identifies Genetic Predictors of High‐Dose Methotrexate‐Induced Mucositis in Pediatric Acute Lymphoblastic Leukemia

Clinical Pharmacology &Therapeutics, EarlyView.
High‐dose methotrexate for pediatric cancer treatment is frequently associated with mucositis, which can lead to delayed or discontinued treatment and impact survival. While individual genetic variants have been implicated, the cumulative impact of genetic variation within relevant biological pathways remains unexplored.
Xiao Yu Cindy Zhang, Erika N. Scott, Hedy Maagdenberg, Alice Man, Kathy H. Li, S. Rod Rassekh, Bruce C. Carleton, Colin J. D. Ross, Wyeth W. Wasserman, Catrina M. Loucks   +9 more
wiley   +1 more source