Results 221 to 230 of about 232,441 (272)

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

<i>Schizosaccharomyces pombe pus1</i> mutants are temperature sensitive due to decay of tRNA^Ile(UAU) by the 5'-3' exonuclease Dhp1, primarily targeting the unspliced pre-tRNA. [PDF]

RNA
Stegemann F, Marcus E, Neupert S, Ostrowski S, Mathews DH, Phizicky EM.   +5 more
europepmc   +1 more source

An E-box element localized in the first intron mediates regulation of the prothymosin alpha gene by c-myc. [PDF]

, 1994
Stefan Gaubatz, Albrecht Meichle, Martin Eilers   +2 more
openalex   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Self-splicing introns in genes of Bastillevirinae bacteriophages. [PDF]

Nucleic Acids Res
Węglewska M, Gracz-Bernaciak J, Bałdysz S, Nowicki G, Barylski J.   +4 more
europepmc   +1 more source

Group II intron self-splicing. Alternative reaction conditions yield novel products.

, 1988
Kevin A. Jarrell, Craig L. Peebles, Rosemary C. Dietrich, Steven L. Romiti, Philip S. Perlman   +4 more
openalex   +1 more source

Assessing Splicing Variants in the PAX6 Gene: A Comprehensive Minigene Approach. [PDF]

J Cell Mol Med
Davydenko K, Filatova A, Skoblov M.
europepmc   +1 more source

Structure of the gene for mouse thymidylate synthase. Locations of introns and multiple transcriptional start sites.

, 1986
T Deng, D W Li, Chung‐Her Jenh, Lee F. Johnson   +3 more
openalex   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source

Association of IL-1RAcP rs16865597 gene polymorphism with susceptibility to essential hypertension: a case-control study in the Chinese Han population. [PDF]

BMC Cardiovasc Disord
Wu F, Liu D, Xia X, Yang X, Huang S, Jiang X, LuLi.   +6 more
europepmc   +1 more source