Results 261 to 270 of about 232,441 (272)

Noncoding function of super enhancer derived <i>Cpox</i> pre-mRNA in modulating neighbouring gene expression and chromatin interactions. [PDF]

RNA Biol
Xie B, Dean A.
europepmc   +1 more source

Clinical Assessment of the Drug–Drug Interaction Potential of Omaveloxolone in Healthy Adult Participants

The Journal of Clinical Pharmacology, EarlyView.
Abstract Omaveloxolone is approved in the United States and the European Union for the treatment of patients with Friedreich ataxia aged ≥16 years. It is mainly metabolized by cytochrome P450 (CYP) 3A4 in vitro. Two drug–drug interaction studies (NCT04008186 and NCT05909644) were performed to evaluate (1) the effect of drug‐metabolizing enzymes (DMEs ...
Hamim Zahir, Masako Murai, Lucy Wu, Michelle Valentine, Scott Hynes   +4 more
wiley   +1 more source

Targeting the splicing factor SNRPB inhibits endometrial cancer progression by retaining the POLD1 intron. [PDF]

Exp Mol Med
Li Y, Chen Z, Xiao H, Liu Y, Zhao C, Yang N, Yuan C, Yan S, Li P.   +8 more
europepmc   +1 more source

N⁶-Methyladenosine (m⁶A)-Circular RNA Pappalysin 1 (circPAPPA) from Cashmere Goats: Identification, Regulatory Network and Expression Potentially Regulated by Methylation in Secondary Hair Follicles Within the First Intron of Its Host Gene. [PDF]

Animals (Basel)
Bai M, Shen J, Fan Y, Xu R, Hui T, Zhu Y, Zhang Q, Zhang J, Wang Z, Bai W.   +9 more
europepmc   +1 more source

Molecular Classification of Endometrial Cancers Using an Integrative DNA Sequencing Panel

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Adoption of molecular classification in endometrial cancer (EC) into clinical practice remains challenging due to complexity in coordination of multiple assays. We aimed to develop a simple molecular technique to classify ECs into four subgroups using our custom‐designed targeted sequencing panel.
Soyoun R. Kim, Leslie Oldfield, Raymond H. Kim, Osvaldo Espin‐Garcia, Kathy Han, Danielle Vicus, Lua Eiriksson, Alicia Tone, Aaron Pollett, Matthew Cesari, Blaise Clarke, Marcus Q. Bernardini, Trevor J. Pugh, Sarah E. Ferguson   +13 more
wiley   +1 more source

Hypoxia-induced ATF3 escalates breast cancer invasion by increasing collagen deposition via P4HA1. [PDF]

Cell Death Dis
Dhamdhere SG, Bansal A, Singh P, Kakani P, Agrawal S, Samaiya A, Shukla S.   +6 more
europepmc   +1 more source

Phylogenetic Analysis of 590 Species Reveals Distinct Evolutionary Patterns of Intron-Exon Gene Structures Across Eukaryotic Lineages. [PDF]

Mol Biol Evol
Glick L, Castiglione S, Loewenthal G, Raia P, Pupko T, Mayrose I.   +5 more
europepmc   +1 more source

Protein-free catalysis of DNA hydrolysis and self-integration by a ribozyme. [PDF]

Nucleic Acids Res
Szokoli D, Mutschler H.
europepmc   +1 more source

Identifying six single nucleotide variants in the COL17A1 gene that alter RNA splicing: database analysis and minigene assays. [PDF]

Sci Rep
Shao Y, Zhang R.
europepmc   +1 more source

RBM4-mediated intron excision of Hsf1 induces BDNF for cerebellar foliation. [PDF]

Commun Biol
Shen CL, Tsai YY, Chou SJ, Chang YM, Tarn WY.   +4 more
europepmc   +1 more source