Results 261 to 270 of about 416,899 (328)

Polygenic risk score and prostate specific antigen predict death from prostate cancer in men with intermediate aggressive cancer

International Journal of Cancer, EarlyView.
What's New? Using 21 SNPs, two novel PRS were constructed and used to develop two new machine‐learning classifiers, one for the detection of prostate cancer and the other for the prediction of its aggressiveness and subsequent mortality. The classifier for disease detection is built using the PRS as the sole feature, whereas the one for disease ...
Leandro Rodrigues Santiago, Efthymios Ladoukakis, Dorota Scibior‐Bentkowska, Belinda Nedjai   +3 more
wiley   +1 more source

VNTR Polymorphisms in the <i>SLC6A3</i> Gene and Their Impact on Time Perception and EEG Activity. [PDF]

Bioengineering (Basel)
Marinho FVC, Teixeira SS, Rebouças Pinto G, de Oliveira T, Yoshioka FKN, Fernandes H, Miranda A, Velasques BB, de Souza E Silva APR, Cagy M, Bastos VHDV.   +10 more
europepmc   +1 more source

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

Skipping of an alternative intron in the srsf1 3' untranslated region increases transcript stability

, 2011
Yoko Akaike, Ken Kurokawa, Keisuke Kajita, Yuki Kuwano, Kiyoshi Masuda, Kensei Nishida, Seung Wan Kang, Toshihito Tanahashi, Kazuhito Rokutan   +8 more
openalex   +2 more sources

Detecting TP53 mutations in paired liquid and tissue biopsies from patients with high‐grade serous ovarian carcinoma

International Journal of Cancer, EarlyView.
What's New? High‐grade serous ovarian carcinoma is often diagnosed at advanced stages due to non‐specific symptoms and the lack of reliable screening methods. This proof‐of‐concept study introduces a novel TP53 mutation panel using unique molecular identifier‐based next‐generation sequencing for sensitive detection of high‐grade serous ovarian ...
Amanda Olsson Widjaja, Peter Micallef, Maria Lycke, Tobias Österlund, Manuel Luna Santamaría, Julia Hedlund Lindberg, Therese Carlsson, Ulf Gyllensten, Anders Ståhlberg, Benjamin Ulfenborg, Anna Linder, Karin Sundfeldt   +11 more
wiley   +1 more source

Genetic and clinical characteristics of Japanese cystinuria with exon and exon-intron boundary variants. [PDF]

Sci Rep
Sakamoto S, Naya Y, Rii J, Taguchi K, Fujimura M, Shigeta Y, Chairoungdua A, Nishimura M, Wakai K, Yamada Y, Zhao X, Imamura Y, Tajima S, Sato N, Hosaka C, Sekine M, Ueda T, Hamamoto S, Yasui T, Kanai Y, Akakura K, Ikehara Y, Anzai N, Ichikawa T.   +23 more
europepmc   +1 more source

Genomic signature driving preinvasive to invasive processes in stage I lung adenocarcinoma

International Journal of Cancer, EarlyView.
What's New? The progression of lung cancer from minimally invasive adenocarcinoma (MIA) to invasive adenocarcinoma (IA) is a complex process involving molecular and microenvironment changes. Key molecular events that drive the invasion process, however, remain poorly characterized. In this comparison of gene profiles and differentially mutated genes in
Biqin Mou, Yishan Duan, Jing Wang, Tiantian Li, Yuwei Huo, Xia Xiao, Conghui Cui, Zhujun Deng, Qiongxia Hu, Juan Jiang, Yiwei Liang, Sifen Lu, Xintong Tao, Kang Xie, Xinru Xiong, Niu Zhu, Liyun Bi, Faqiang Zhang, Weimin Li, Bojiang Chen   +19 more
wiley   +1 more source

Genetic variation within ABCE1 is associated with the chicken L blood system. [PDF]

Poult Sci
Fulton JE, McCarron AM, Wolc A, Mullen A, Foerstner C, Sparling B, Drobik-Czwarno W, Taylor RL.   +7 more
europepmc   +1 more source

Isolation and Characterization of Group II Introns from Pseudomonas alcaligenes and Pseudomonas putida

, 2001
Chew Chieng Yeo, Sheree Yiin, Bee Huat Tan, Chit Laa Poh   +3 more
openalex   +2 more sources

The hidden regulators: Non‐coding RNAs in KMT2A‐rearranged acute lymphoblastic leukemia

International Journal of Cancer, EarlyView.
Abstract Acute lymphoblastic leukemia (ALL) driven by KMT2A rearrangements (KMT2A‐r) is an aggressive hematologic malignancy with poor prognosis and a high incidence in infants. While KMT2A fusion proteins drive leukemogenesis through transcriptional dysregulation, recent discoveries have highlighted the pivotal role of non‐coding RNAs (ncRNAs) in ...
Maria Augusta Poersch, Ana Carolina Rodrigues, Priscila Elias Ferreira Stricker, Alexandre Luiz Korte Azevedo, Daniel Pacheco Bruschi, Jaqueline Carvalho de Oliveira   +5 more
wiley   +1 more source