Results 281 to 290 of about 413,811 (335)

Alternatively spliced isoforms of IRF7 differentially regulate interferon expression to tune response to viral infection. [PDF]

Cell Rep
Panthi A, Ferretti MB, Howard O, Pokharel SM, McCracken R, Boudreault S, Quesnel-Vallieres M, Li Q, Cherry S, Lynch KW.   +9 more
europepmc   +1 more source

RNA editing in trans-splicing intron sequences of nad2 mRNAs in Oenothera mitochondria.

, 1992
Stefan Binder, Anita Marchfelder, Axel Brennicke, Bernd Wissinger   +3 more
openalex   +1 more source

Mechanisms of enhancer‐driven oncogene activation

International Journal of Cancer, EarlyView.
Abstract An aggressive subtype of acute myeloid leukemia (AML) is caused by enhancer hijacking resulting in MECOM overexpression. Several chromosomal rearrangements can lead to this: the most common (inv(3)/t(3;3)) results in a hijacked GATA2 enhancer, and there are several atypical MECOM rearrangements involving enhancers from other hematopoietic ...
Joyce Vriend, Ruud Delwel, Dorien Pastoors   +2 more
wiley   +1 more source

A single donor cassette enables site-specific knock-in at either the αAmy3 or αAmy8 locus in rice cells via CRISPR/Cas9. [PDF]

Appl Microbiol Biotechnol
Sinaga DS, Huang PY, Huang CK, Lu CA, Huang LF.   +4 more
europepmc   +1 more source

Polygenic risk score and prostate specific antigen predict death from prostate cancer in men with intermediate aggressive cancer

International Journal of Cancer, EarlyView.
What's New? Using 21 SNPs, two novel PRS were constructed and used to develop two new machine‐learning classifiers, one for the detection of prostate cancer and the other for the prediction of its aggressiveness and subsequent mortality. The classifier for disease detection is built using the PRS as the sole feature, whereas the one for disease ...
Leandro Rodrigues Santiago, Efthymios Ladoukakis, Dorota Scibior‐Bentkowska, Belinda Nedjai   +3 more
wiley   +1 more source

NRDE2 Interacts with an Early Transcription Elongation Complex and Widely Impacts Gene Expression. [PDF]

Int J Mol Sci
Srbic M, Belhaouari C, Raffel R, Lemaire L, Barbier J, Bossuyt J, Akkawi C, Contreras X, Kiernan R.   +8 more
europepmc   +1 more source

A complex response element in intron 1 of the androgen-regulated 20-kDa protein gene displays cell type-dependent androgen receptor specificity.

, 1993
K C Ho, Keith B. Marschke, Jian Tan, Stephanie Power, Elizabeth M. Wilson, Frank S. French   +5 more
openalex   +1 more source

New cell lines expanding the diversity of Ewing sarcoma models

International Journal of Cancer, EarlyView.
What's New? A chromosomal translocation between the EWSR1 and ETS genes is the key oncogenic driver in Ewing sarcoma. EWSR1::FLI1, the most frequent fusion, is subdivided into different fusion types with unclear prognostic relevance. Here, the authors describe the establishment and characterization of four new, intrinsically immortal, patient‐derived ...
Maximilian Kerkhoff, Christiane Schaefer, Wilhelm G. Dirks, Dawid Krzeciesa, Maximilian Bretschneider, Pauline R. Plaumann, Wiebke K. Guder, Arne Streitbürger, Sonja Herter, Heike Peterziel, Ina Oehme, Felina Zahnow, Thomas G. P. Grünewald, Uta Dirksen   +13 more
wiley   +1 more source

The mitochondrial DNA copy number and ovary‐related reproductive disorders: A bidirectional two‐sample Mendelian randomization study

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 112-120, April 2025.
Abstract Objective In the present study, a bidirectional two‐sample Mendelian randomization approach was utilized to explore potential causal relationships between mitochondrial DNA copy number (mtDNA‐CN) and ovary‐related reproductive disorders (ORRDs), including ovarian dysfunction, ovarian cyst, polycystic ovary syndrome (PCOS), premature ovarian ...
Ke Peng, Xiao Han, Congquan Wu, Qiaowen Lu, Shujun Gao   +4 more
wiley   +1 more source