Results 21 to 30 of about 401,804 (292)

First Identification of Rare Exonic and Deep Intronic Splice-Altering Variants in Patients With Beta-Sarcoglycanopathy

open access: yesFrontiers in Pediatrics, 2022
BackgroundThe precise genetic diagnosis of a sarcoglycanopathy or dystrophinopathy is sometimes extremely challenging, as pathogenic non-coding variants and/or complex structural variants do exist in DMD or sarcoglycan genes.
Zhiying Xie   +16 more
doaj   +1 more source

Molecular Characterization of Three B-1,4-Endoglucanase Genes in Pratylenchus loosi and Functional Analysis of Pl-eng-2 Gene

open access: yesPlants, 2021
Pratylenchus loosi is an important root-lesion nematode that causes damage to tea plantations in Iran and all over the world. The present study reports on the characterization and evolution of three ß-1,4-endoglucanase genes: Pl-eng-2, Pl-eng-3 and Pl ...
Negin Mirghasemi   +4 more
doaj   +1 more source

A Bidirectional LSTM-RNN and GRU Method to Exon Prediction Using Splice-Site Mapping

open access: yesApplied Sciences, 2022
Deep Learning techniques (DL) significantly improved the accuracy of predictions and classifications of deoxyribonucleic acid (DNA). On the other hand, identifying and predicting splice sites in eukaryotes is difficult due to many erroneous discoveries ...
Peren Jerfi CANATALAY, Osman Nuri Ucan
doaj   +1 more source

The insertion of a mitochondrial selfish element into the nuclear genome and its consequences

open access: yesEcology and Evolution, 2020
Homing endonucleases (HE) are enzymes capable of cutting DNA at highly specific target sequences, the repair of the generated double‐strand break resulting in the insertion of the HE‐encoding gene (“homing” mechanism).
Julien Y. Dutheil   +4 more
doaj   +1 more source

Systematic Identification and Functional Validation of New snoRNAs in Human Muscle Progenitors

open access: yesNon-Coding RNA, 2021
Small non-coding RNAs (sncRNAs) represent an important class of regulatory RNAs involved in the regulation of transcription, RNA splicing or translation.
Baptiste Bogard   +2 more
doaj   +1 more source

Intron Mobility: Invasive introns [PDF]

open access: yesCurrent Biology, 1994
The evidence that introns in fungal and plant organellar DNAs are mobile genetic elements has strengthened significantly; like Shaw's cockney heroine, Eliza Doolittle, they cannot help but betray their origins.
openaire   +2 more sources

Rescue of splicing-mediated intron loss maximizes expression in lentiviral vectors containing the human ubiquitin C promoter. [PDF]

open access: yes, 2014
Lentiviral vectors almost universally use heterologous internal promoters to express transgenes. One of the most commonly used promoter fragments is a 1.2-kb sequence from the human ubiquitin C (UBC) gene, encompassing the promoter, some enhancers, first
Cooper, Aaron R   +3 more
core   +1 more source

Exon-intron structure and sequence variation of the calreticulin gene among Rhipicephalus sanguineus group ticks [PDF]

open access: yes, 2016
Background: Calreticulin proteins (CRTs) are important components of tick saliva, which is involved in the blood meal success, pathogen transmission and host allergic responses.
Dantas-Torres, Filipe   +6 more
core   +2 more sources

High-yield production of multiple O-methylated phenylpropanoids by the engineered Escherichia coli–Streptomyces cocultivation system

open access: yesMicrobial Cell Factories, 2019
Background O-Methylated phenylpropanoids, which are generally present in small amounts in plants, have improved or distinct biological activities and pharmacological properties as opposed to their unmethylated counterparts.
Heqing Cui   +6 more
doaj   +1 more source

Applied Barcoding: The Practicalities of DNA Testing for Herbals

open access: yesPlants, 2020
DNA barcoding is a widely accepted technique for the identification of plant materials, and its application to the authentication of commercial medicinal plants has attracted significant attention.
Caroline Howard   +2 more
doaj   +1 more source

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