Results 31 to 40 of about 401,804 (292)

RHD Genotypes in a Chinese Cohort of Pregnant Women

open access: yesFrontiers in Genetics, 2021
RHD variants in D¯ Chinese pregnant women arose difficulties in management during pregnancy. Therefore, this study aims to precisely manage D¯ pregnant women by evaluating the spectrum of RHD mutations in D¯ pregnant women and getting insight into the ...
Jianjun Zhang   +17 more
doaj   +1 more source

Interplay of heavy chain introns influences efficient transcript splicing and affects product quality of recombinant biotherapeutic antibodies from CHO cells

open access: yesmAbs, 2023
Introns are included in genes encoding therapeutic proteins for their well-documented function of boosting expression. However, mis-splicing of introns in recombinant immunoglobulin (IgG) heavy chain (HC) transcripts can produce amino acid sequence ...
Emma Kelsall   +5 more
doaj   +1 more source

An orchestrated intron retention program in meiosis controls timely usage of transcripts during germ cell differentiation [PDF]

open access: yes, 2017
Global transcriptome reprogramming during sper-matogenesis ensures timely expression of factors in each phase of male germ cell differentiation. Sper-matocytes and spermatids require particularly exten-sive reprogramming of gene expression to switch from
Alberdi, Antonio J.   +9 more
core   +2 more sources

Proximity to the Promoter and Terminator Regions Regulates the Transcription Enhancement Potential of an Intron

open access: yesFrontiers in Molecular Biosciences, 2021
An evolutionarily conserved feature of introns is their ability to enhance expression of genes that harbor them. Introns have been shown to regulate gene expression at the transcription and post-transcription level.
Katherine Dwyer   +3 more
doaj   +1 more source

Rapid Targeted Gene Disruption in Bacillus Anthracis [PDF]

open access: yes, 2013
Anthrax is a zoonotic disease recognized to affect herbivores since Biblical times and has the widest range of susceptible host species of any known pathogen.
Ellington, Andrew   +9 more
core   +3 more sources

An overview of RNA splicing and functioning of splicing factors in land plant chloroplasts

open access: yesRNA Biology, 2022
RNA splicing refers to a process by which introns of a pre-mRNA are excised and the exons at both ends are joined together. Chloroplast introns are inherently self-splicing ribozymes, but over time, they have lost self-splicing ability due to the ...
Xuemei Wang   +4 more
doaj   +1 more source

Intronization, de-intronization and intron sliding are rare in Cryptococcus [PDF]

open access: yesBMC Evolutionary Biology, 2009
Eukaryotic pre-mRNA gene transcripts are processed by the spliceosome to remove portions of the transcript, called spliceosomal introns. The spliceosome recognizes intron boundaries by the presence of sequence signals (motifs) contained in the actual transcript, thus sequence changes in the genome that affect existing splicing signals or create new ...
openaire   +3 more sources

Novel Genomic and Evolutionary Perspective of Cyanobacterial tRNAs

open access: yesFrontiers in Genetics, 2017
Transfer RNA (tRNA) plays a central role in protein synthesis and acts as an adaptor molecule between an mRNA and an amino acid. A tRNA has an L-shaped clover leaf-like structure and contains an acceptor arm, D-arm, D-loop, anti-codon arm, anti-codon ...
Tapan K. Mohanta   +3 more
doaj   +1 more source

Organization and sequence of the gene encoding the human acrosin-trypsin inhibitor (HUSI-II) [PDF]

open access: yes, 1993
A complete cDNA encoding the acrosin-trypsin inhibitor, HUSI-II, was used as a probe to isolate genomic clones from a human placenta library. Three clones which cover the entire HUSI-II gene were isolated and characterized.
Abelson   +28 more
core   +1 more source

Characterization of Global DNA Methylation in Different Gene Regions Reveals Candidate Biomarkers in Pigs with High and Low Levels of Boar Taint

open access: yesVeterinary Sciences, 2020
DNA methylation of different gene components, including different exons and introns, or different lengths of exons and introns is associated with differences in gene expression.
Xiao Wang, Haja N. Kadarmideen
doaj   +1 more source

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