Results 31 to 40 of about 245,400 (261)

Coevolution Theory of the Genetic Code at Age Forty: Pathway to Translation and Synthetic Life

open access: yesLife, 2016
The origins of the components of genetic coding are examined in the present study. Genetic information arose from replicator induction by metabolite in accordance with the metabolic expansion law.
J. Tze-Fei Wong   +4 more
doaj   +1 more source

Intron Evolution in Saccharomycetaceae [PDF]

open access: yesGenome Biology and Evolution, 2014
Introns in protein-coding genes are very rare in hemiascomycetous yeast genomes. It has been suggested that these species have experienced extensive intron loss during their evolution from the postulated intron-rich fungal ancestor. However, no intron-devoidy east species have been identified and some of the introns remaining within the genomes of ...
Hooks, Katarzyna B   +2 more
openaire   +3 more sources

Expression of the C-allele of intronic rs8192675 in SLC2A2 is associated with improved glucose response to metformin [PDF]

open access: yesGenetics and Molecular Biology
Glucose is a critical nutrient for energy metabolism. The SLC2A2 gene is essential for glucose sensing and homeostasis, as it encodes the facilitated glucose transporter GLUT2. During diabetes treatment, the C-allele of rs8192675 in SLC2A2 has been found
Wanjun Wang   +4 more
doaj   +1 more source

A Review for the Special Issue on Paramecium as a Modern Model Organism

open access: yesMicroorganisms, 2023
This review provides background and perspective for the articles contributing to the Special Issue of MDPI Micro-organisms on Paramecium as a Modern Model Organism.
Judith Van Houten
doaj   +1 more source

Improved osteogenic vector for non-viral gene therapy [PDF]

open access: yesEuropean Cells & Materials, 2016
Therapeutic compensation of deficient bone regeneration is a challenging task and a topic of on-going search for novel treatment strategies. One promising approach for improvement involves non-viral gene delivery using the bone morphogenetic protein-2 ...
ARA Hacobian   +7 more
doaj   +1 more source

Periodicities in introns

open access: yesNucleic Acids Research, 1987
The sequence information for the splicing process of introns is found in the consensus sequences at the two splice sites. For long introns, of 300 or more nucleotides, the middle regions may provide additional specificity for splicing which can be investigated by defining an adequate quantitative parameter.
Arquès DG, Michel CJ
openaire   +4 more sources

Substitution of the α-lactalbumin transcription unit by a CAT cDNA within a BAC clone silenced the locus in transgenic mice without affecting the physically linked Cyclin T1 gene

open access: yesGenetics Selection Evolution, 2003
We recently reported that a goat bacterial artificial chromosome (BAC) clone conferred site-independent expression in transgenic mice of the two loci present within its insert, the ubiquitously expressed Cyclin T1 and the mammary specific β-lactalbumin ...
Jean-Luc Vilotte   +6 more
doaj   +1 more source

Global Characterization of Fungal Mitogenomes: New Insights on Genomic Diversity and Dynamism of Coding Genes and Accessory Elements

open access: yesFrontiers in Microbiology, 2021
Fungi comprise a great diversity of species with distinct ecological functions and lifestyles. Similar to other eukaryotes, fungi rely on interactions with prokaryotes and one of the most important symbiotic events was the acquisition of mitochondria ...
Paula L. C. Fonseca   +11 more
doaj   +1 more source

A New Reference Genome Assembly for the Microcrustacean Daphnia pulex

open access: yesG3: Genes, Genomes, Genetics, 2017
Comparing genomes of closely related genotypes from populations with distinct demographic histories can help reveal the impact of effective population size on genome evolution. For this purpose, we present a high quality genome assembly of Daphnia pulex (
Zhiqiang Ye   +12 more
doaj   +1 more source

Taxonomy of introns and the evolution of minor introns

open access: yesNucleic Acids Research
Abstract Classification of introns, which is crucial to understanding their evolution and splicing, has historically been binary and has resulted in the naming of major and minor introns that are spliced by their namesake spliceosome. However, a broad range of intron consensus sequences exist, leading us to here reclassify introns as ...
Anouk M Olthof   +9 more
openaire   +3 more sources

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