Results 311 to 320 of about 482,093 (336)

AAV‐Based Intracerebral Administration of BDNF Promotes Myelin Repair and Cognitive Improvement After Cuprizone‐Induced Demyelination

Glia, EarlyView.
AAV‐BDNF improves cognitive performance after cuprizone‐induced de‐myelination. BDNF promotes OPC maturation and enhances remyelination in the corpus callosum. Mitochondrial integrity is preserved through reduced swelling and improved morphology. ABSTRACT Multiple sclerosis (MS) is a chronic neurological disorder involving immune‐mediated demyelination
Yousra El Ouaamari, Leonardo Ricciardi, Sanne van der Heijden, Antonia Peter, Jorrit De Waele, Jasper Van den Bos, Debby Van Dam, Elke Calus, Sarah Kuhn, Waleed Marei, Yvonne Dombrowski, Marleen Verhoye, Peter Ponsaerts, Inez Wens, Nathalie Cools   +14 more
wiley   +1 more source

Antisense oligonucleotide therapy for patients with Friedreich's ataxia carrying the c.165+5G>C splicing mutation. [PDF]

Mol Ther Nucleic Acids
Yameogo P, Aguilar S, Prakash TP, Rigo F, Lynch DR, Napierala JS, Napierala M.   +6 more
europepmc   +1 more source

Hypothalamic Astrocytes Exhibit Glycolytic Features Making Them Prone for Glucose Sensing

Glia, EarlyView.
Hypothalamic astrocytes versus cortical astrocytes: are more glycolytic due to high Pkm2, Glut1 and Mct4 expression do not exhibit glutamate‐induced glycolysis detect glucose concentration variations via an AMPK sensor with altered lactate production. ABSTRACT In the hypothalamus, detection of energy substrates such as glucose is essential to regulate ...
Sarah Geller, Nadège Zanou, Sylviane Lagarrigue, Tamara Zehnder, Cathy Gouelle, Tania Santoro, Cendrine Repond, Paola Bezzi, Francesca Amati, Anne‐Karine Bouzier‐Sore, Ariane Sharif, Luc Pellerin   +11 more
wiley   +1 more source

The Relevance of G-Quadruplexes in Gene Promoters and the First Introns Associated with Transcriptional Regulation in Breast Cancer. [PDF]

Int J Mol Sci
Shu H, Xiao K, Zhu W, Zhang R, Tao T, Sun X.   +5 more
europepmc   +1 more source

Queuosine is incorporated into precursor tRNA before splicing. [PDF]

Nat Commun
Guo W, Kaczmarczyk I, Kopietz K, Flegler F, Russo S, Cigirgan E, Chramiec-Głąbik A, Koziej Ł, Cirzi C, Peschek J, Reuter K, Helm M, Glatt S, Tuorto F.   +13 more
europepmc   +1 more source

Investigation of growth traits in Turkish Merino lambs using multi-locus GWAS approaches: Karacabey Merino. [PDF]

BMC Vet Res
Yaman Y, Aymaz R, Keleş M, Kişi YE, Hatipoğlu E, Özdemir A, Çetinkaya E.   +6 more
europepmc   +1 more source

The transcription factor CfHac1 regulates the degradation of ubiquitin-mediated ER-associated misfolded proteins and pathogenicity in Colletotrichum fructicola. [PDF]

Stress Biol
Li S, Guo Y, Zhang S, Li H.
europepmc   +1 more source

TP53 minigene analysis of 161 sequence changes provides evidence for role of spatial constraint and regulatory elements on variant-induced splicing impact. [PDF]

NPJ Genom Med
Canson DM, Llinares-Burguet I, Fortuno C, Sanoguera-Miralles L, Bueno-Martínez E, de la Hoya M, Spurdle AB, Velasco-Sampedro EA.   +7 more
europepmc   +1 more source