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A Transcriptional Variant of Anaplastic Lymphoma Kinase Promotes Apoptosis in Ovarian High‐Grade Serous Carcinoma

Molecular Carcinogenesis, EarlyView.
ABSTRACT The current study aims to delineate the role of a novel anaplastic lymphoma kinase (ALK) transcript, ALKATI, in ovarian high‐grade serous carcinoma (HGSC). Overexpressed ALKATI exhibited both cytoplasmic and nuclear localization in HGSC cells, whereas full‐length ALK was predominantly cytoplasmic.
Ako Yokoi, Daigo Yoshimori, Yasuko Oguri, Miki Hashimura, Makoto Saegusa   +4 more
wiley   +1 more source

Interactive Bioinformatics Lab: Using Genomic Databases for Active Learning in Dentistry

Journal of Dental Education, EarlyView.
François Isnaldo Dias Caldeira, Raquel Mantuaneli Scarel‐Caminaga   +1 more
wiley   +1 more source

Human-specific genomic evolution of a regulatory network enables fine-tuning of N-cadherin gene expression. [PDF]

Cell Mol Life Sci
Erdmann É, Agolli S, Fix S, Cottard F, Keyser C, Zvenigorosky V, Gonzalez A, Haili Z, Kieffer B, Céraline J.   +9 more
europepmc   +1 more source

Prp16 enables efficient splicing of introns with diverse exonic consensus elements in the short-intron rich <i>Cryptococcus neoformans</i> transcriptome. [PDF]

RNA Biol
Negi MS, Krishnan VP, Saraf N, Vijayraghavan U.   +3 more
europepmc   +1 more source

Direct repeats found in the vicinity of intron splice sites. [PDF]

Naturwissenschaften
Rogers SO, Bendich AJ.
europepmc   +1 more source

Escape from X-chromosome inactivation at KDM5C is driven by promoter-proximal DNA elements and enhanced by domain context. [PDF]

Hum Mol Genet
Peeters S, Baldry S, Korecki AJ, Srinivasan A, Wasserman WW, Simpson EM, Brown CJ.   +6 more
europepmc   +1 more source

Sequence-dependent and -independent effects of intron-mediated enhancement learned from thousands of random introns. [PDF]

Nucleic Acids Res
Kowal EJK, Sakai Y, McGurk MP, Pasetsky ZJ, Burge CB.   +4 more
europepmc   +1 more source

Competing 5’ splice sites of SRC1/HEH1 are marked for alternative splicing by U5 and U6 snRNAs during the B to Bact transition of the spliceosome

Banyal AK, Choudhuri P, Pillai BR, Varikkapulakkal A, Mishra SK.   +4 more
europepmc   +1 more source

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Origin of introns by ‘intronization’ of exonic sequences

Trends in Genetics, 2008
The mechanisms of spliceosomal intron creation have proved elusive. Here we describe a new mechanism: the recruitment of internal exonic sequences ('intronization') in Caenorhabditis species. The numbers of intronization events and introns gained by other mechanisms are similar, suggesting that intronization significantly contributes to recent intron ...
Irimia, Manuel, Rukov, Jakob Lewin, Penny, David, Vinther, Jeppe, Garcia-Fernandez, Jordi, Roy, Scott William   +5 more
openaire   +4 more sources

Frühe Introns – späte Introns?

Biologie in unserer Zeit, 1995
AbstractIntrons nennt man Nucleinsäuresequenzen, die mitten in Genregionen eingefügt sind, letztlich aber nicht in Polypeptidsequenzen übersetzt werden. Auch Prokaryoten und sogar Viren können unterbrochene Gene besitzen, aber nur bei den Eukaryoten findet man die „klassischen”︁ Introns, die dort fast alle Strukturgene zerstückeln.
openaire   +2 more sources