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A Transcriptional Variant of Anaplastic Lymphoma Kinase Promotes Apoptosis in Ovarian High‐Grade Serous Carcinoma

open access: yesMolecular Carcinogenesis, EarlyView.
ABSTRACT The current study aims to delineate the role of a novel anaplastic lymphoma kinase (ALK) transcript, ALKATI, in ovarian high‐grade serous carcinoma (HGSC). Overexpressed ALKATI exhibited both cytoplasmic and nuclear localization in HGSC cells, whereas full‐length ALK was predominantly cytoplasmic.
Ako Yokoi   +4 more
wiley   +1 more source

Interactive Bioinformatics Lab: Using Genomic Databases for Active Learning in Dentistry

open access: yes
Journal of Dental Education, EarlyView.
François Isnaldo Dias Caldeira   +1 more
wiley   +1 more source

Human-specific genomic evolution of a regulatory network enables fine-tuning of N-cadherin gene expression. [PDF]

open access: yesCell Mol Life Sci
Erdmann É   +9 more
europepmc   +1 more source
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Origin of introns by ‘intronization’ of exonic sequences

Trends in Genetics, 2008
The mechanisms of spliceosomal intron creation have proved elusive. Here we describe a new mechanism: the recruitment of internal exonic sequences ('intronization') in Caenorhabditis species. The numbers of intronization events and introns gained by other mechanisms are similar, suggesting that intronization significantly contributes to recent intron ...
Irimia, Manuel   +5 more
openaire   +4 more sources

Frühe Introns – späte Introns?

Biologie in unserer Zeit, 1995
AbstractIntrons nennt man Nucleinsäuresequenzen, die mitten in Genregionen eingefügt sind, letztlich aber nicht in Polypeptidsequenzen übersetzt werden. Auch Prokaryoten und sogar Viren können unterbrochene Gene besitzen, aber nur bei den Eukaryoten findet man die „klassischen”︁ Introns, die dort fast alle Strukturgene zerstückeln.
openaire   +2 more sources

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