Results 81 to 90 of about 232,441 (272)
Keep Me Around: Intron Retention Detection and Analysis [PDF]
arXiv, 2015 We present a tool, keep me around (kma), a suite of python scripts and an R package that finds retained introns in RNA-Seq experiments and incorporates biological replicates to reduce the number of false positives when detecting retention events. kma uses the results of existing quantification tools that probabilistically assign multi-mapping reads ...
arxiv
Structural Insights into an Antiparallel Chair‐Type G‐Quadruplex From the Intron of NOP56 Oncogene
Advanced Science, EarlyView.This study first reports that the intron 1 of NOP56 oncogene forms an antiparallel chair‐type G4 structure composed of two G‐tetrads and one C∙G∙C∙G tetrad. NOP56 gene transcription can be inhibited by PDS that binds and stabilizes NOP56‐G4. Solution NMR structures of the free NOP56‐G4 and NOP56‐G4‐PDS complex provide valuable insights into G4 ...
Zhenzhen Yan +11 more
wiley +1 more source
A powerful global test for spliceQTL effects
Biometrical Journal, Volume 65, Issue 1, January 2023., 2023 Abstract Statistical methods to test for effects of single nucleotide polymorphisms (SNPs) on exon inclusion exist but often rely on testing of associations between multiple exon–SNP pairs, with sometimes subsequent summarization of results at the gene level. Such approaches require heavy multiple testing corrections and detect mostly events with large
Renee X. de Menezes +4 more
wiley +1 more source
Chromatin Organization Governs Transcriptional Response and Plasticity of Cancer Stem Cells
Advanced Science, EarlyView.Through a combination of transcriptomic and histone mapping studies integrated with chromatin imaging, we define how chromatin organization in nanoscale packing domains fine tunes the plasticity of cancer stem cells (CSCs) driving evasion from and survival after chemotherapy.
Yinu Wang +20 more
wiley +1 more source
Comparative analysis of the nucleotide composition biases in exons and introns of human genes [PDF]
arXiv, 2010 The nucleotide composition of human genes with a special emphasis on transcription-related strand asymmetries is analyzed. Such asymmetries may be associated with different mutational rates in two principal factors. The first one is transcription-coupled repair and the second one is the selective pressure related to optimization of the translation ...
arxiv
Advanced Science, EarlyView.Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei +15 more
wiley +1 more source
Cancer Communications, Volume 42, Issue 12, Page 1331-1346, December 2022., 2022 Abstract Background Although programmed cell death 1 (PD‐1) blockade plus chemotherapy can significantly prolong the progression‐free survival (PFS) and overall survival (OS) in first‐line settings in patients with driver‐negative advanced non‐small‐cell lung cancer (NSCLC), the predictive biomarkers remain undetermined.
Fengying Wu +39 more
wiley +1 more source
Mitochondrial DNA. Part B. Resources, 2018 Only two mitochondrial (mt) genomes had been reported in members of the red algal order Batrachospermales, which are confined to freshwater habitats. Additional mt genomes of six representative members (Batrachospermum macrosporum, Kumanoa ambigua, K ...
Monica O. Paiano +6 more
doaj +1 more source
DNA methylation at a CCGG sequence in the large intron of the rabbit β-globin gene: tissue-specific variations [PDF]
, 1978 Cees Waalwijk, Richard A. Flavell
openalex +1 more source
Advanced Science, EarlyView.Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng +11 more
wiley +1 more source