Results 171 to 180 of about 292,600 (397)
Introns increase transcriptional efficiency in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America, 1988 Experiments were designed to test the effect of introns on gene expression in transgenic mice. Four different pairs of gene constructs, which were identical except that one member of each pair lacked all introns, were compared for expression of mRNA ...
R. Brinster +4 more
semanticscholar +1 more source
, 2006 If genome space is finite with little, if any, DNA that is not functional under some circumstance, then potential conflicts between different forms of genomic information must be resolved by appropriate trade-offs. These trade-offs sometimes require that genes accommodate spacers, introns, and simple sequence elements.
openaire +2 more sources
Advanced Science, EarlyView.The splicing factor PTBP3 promotes COX11 exon skipping, allowing gastric cancer organoids to evade cuproptosis. Antisense oligonucleotide drugs targeting PTBP3‐mediated COX11 alternative splicing, in combination with copper ionophores, promote cuproptosis in organoids, thereby providing a therapeutic approach for gastric cancer peritoneal metastasis ...
Yajing Zhou +11 more
wiley +1 more source
Relationships among the nucleotide content of human genome sequence, gene structure, and gene expression features (PhD synopsis) [PDF]
arXiv, 2010 The Dissertation is focused on the studies of associations between functional elements in human genome and their nucleotide structure. The asymmetry in nucleotide content (skew, bias) was chosen as the main feature for nucleotide structure. A significant difference in nucleotide content asymmetry was found for human exons vs. introns.
arxiv
Impact of Tandem Repeats on the Scaling of Nucleotide Sequences
, 2005 Techniques such as detrended fluctuation analysis (DFA) and its extensions have been widely used to determine the nature of scaling in nucleotide sequences.
Bashir R. +4 more
core +1 more source
Advanced Science, EarlyView.PRMT1 drives carboplatin resistance and tumor progression in head and neck squamous cell carcinoma (HNSCC) through a novel, methyltransferase‐independent mechanism. It recruits the SWI/SNF complex to activate IGF2BP2, promoting tumor growth and carboplatin resistance. PBX2 upregulates PRMT1, reinforcing this pathway. This study uncovers a non‐catalytic
Shixian Liu +22 more
wiley +1 more source
ReadsMap: a new tool for high precision mapping of DNAseq and RNAseq read sequences [PDF]
arXiv, 2019 There are currently plenty of programs available for mapping short sequences (reads) to a genome. Most of them, however, including such popular and actively developed programs as Bowtie, BWA, TopHat and many others, are based on Burrows-Wheeler Transform (BWT) algorithm.
arxiv
PIntron: a Fast Method for Gene Structure Prediction via Maximal Pairings of a Pattern and a Text [PDF]
, 2010 Current computational methods for exon-intron structure prediction from a cluster of transcript (EST, mRNA) data do not exhibit the time and space efficiency necessary to process large clusters of over than 20,000 ESTs and genes longer than 1Mb ...
Bonizzoni, Paola +3 more
core
Integrated evolution of ribosomal RNAs, introns, and intron nurseries [PDF]
Genetica, 2018 The initial components of ribosomes first appeared more than 3.8 billion years ago during a time when many types of RNAs were evolving. While modern ribosomes are complex molecular machines consisting of rRNAs and proteins, they were assembled during early evolution by the association and joining of small functional RNA units. Introns may have provided
openaire +3 more sources
Microglial MS4A4A Protects against Epileptic Seizures in Alzheimer's Disease
Advanced Science, EarlyView.This study has unveiled significant new insights into the role of MS4A4A in Alzheimer's disease‐related epilepsy, highlighting its impact on microglial phagocytosis, mitochondrial metabolism, and cytoskeleton, and demonstrating its therapeutic potential in epilepsy management.
Meng Jiang +10 more
wiley +1 more source