Results 61 to 70 of about 152,197 (251)
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
, 2012 (A) Frequencies of introns containing CpG islands at different positions. (B) Locations of CpG islands in the first introns. 500 introns are selected randomly from the first introns.
Dan Chen (32468) +2 more
core +1 more source
Effect of 5'UTR introns on gene expression in
, 2006 Background The majority of introns in gene transcripts are found within the coding sequences (CDSs). A small but significant fraction of introns are also found to reside within the untranslated regions (5'UTRs and 3'UTRs) of expressed sequences ...
Chung, Betty Y. W. +15 more
core +3 more sources
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
Twintrons: Introns-within-introns in the chloroplast genes of Euglena gracilis.
, 1992 The chloroplast genes of Euglena gracilis contain more than 100 introns. A comparison of intron content and position among plastid and prokaryote genes has led to the hypothesis that introns have been inserted into chloroplast genes during evolution ...
Copertino, Donald Woodward.
core +5 more sources
Bi‐ and Mono‐Allelic RFC1 Expansion in a North American Cohort With Idiopathic Axonal Neuropathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective RFC1 biallelic repeat expansion is increasingly recognized as a cause of chronic idiopathic axonal polyneuropathy (CIAP), but it remains challenging to know who to test. This study aims to determine the prevalence of biallelic and monoallelic RFC1 expansions and their corresponding neuropathy phenotypes in CIAP patients and identify ...
Amro M. Stino +25 more
wiley +1 more source
Recent mobility of plastid encoded group II introns and twintrons in five strains of the unicellular red alga Porphyridium [PDF]
PeerJ, 2015 Group II introns are closely linked to eukaryote evolution because nuclear spliceosomal introns and the small RNAs associated with the spliceosome are thought to trace their ancient origins to these mobile elements.
Marie-Mathilde Perrineau +3 more
doaj +2 more sources
Phase distribution of spliceosomal introns: implications for intron origin
BMC Evolutionary Biology, 2006 Background The origin of spliceosomal introns is the central subject of the introns-early versus introns-late debate. The distribution of intron phases is non-uniform, with an excess of phase-0 introns.
Yoshihama Maki +2 more
doaj +1 more source
Evolution of the Exon-Intron Structure in Ciliate Genomes. [PDF]
PLoS ONE, 2016 A typical eukaryotic gene is comprised of alternating stretches of regions, exons and introns, retained in and spliced out a mature mRNA, respectively.
Vladyslav S Bondarenko +1 more
doaj +1 more source
Repetitive elements in the introns.
, 2012 The repetitive elements are represented as black lines in the introns, where other regions are represented as gray spaces. The values along the vertical coordinates represent the numbers of introns (500 introns are selected randomly from the first ...
Dan Chen (32468) +2 more
core +1 more source