Results 111 to 120 of about 180,067 (246)
Call of the Void Scale: scale development, validation and psychometric properties
Frontiers in PsychiatryBackgroundThe inexplicable thought of jumping from a bridge, driving into oncoming traffic or walking in front of an oncoming train is known as the Call of the Void (COV) phenomenon.
Lara Wiesmann +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Efficient intrusion detection scheme based on SVM
, 2013 The network intrusion detection problem is the focus of current academic research. In this paper, we propose to use Support Vector Machine (SVM) model to identify and detect the network intrusion problem, and simultaneously introduce a new optimization ...
Zhou, Guangping, Shrestha, Anup
core +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Towards Configured Intrusion Detection Systems [PDF]
, 2016 This paper studies the challenges in the current intrusion detection system and comparatively analyzes the active and passive response systems. The paper studies the existing IDS and their usefulness in detecting and preventing attacks in any type of ...
Gagan Deep Sharma, Vivek Kumar
core
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Intrusion Detection System based on Ant [PDF]
, 2017 Challenge of designing and building of the current Network Intrusion Detection System not only improves the ability for discriminating the improper internet behaviors but also considers the plenty of computer resources which will be cost during the ...
H.Fathima
core
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source