Results 71 to 80 of about 119,386 (290)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

The Moderating Factors of Click on Intrusive Online Advertising [PDF]

Journal of Emerging Trends in Marketing and Management, 2017
The advent of new media such as Internet, has allowed the advertising communication a new boom. Now integrated into the communication strategy, online advertising is not only means of budgetary savings but also an essential tool for the brand and sales ...
FAKHIR, SARAH
doaj  

Biomechanics Strategies for Space Closure in Deep Overbite

Journal of Dentistry Indonesia, 2013
Space closure is an interesting aspect of orthodontic treatment related to principles of biomechanics. It should be tailored individually based on patient’s diagnosis and treatment plan. Understanding the space closure biomechanics basis leads to achieve
Harryanto Wijaya, Isnani Jenie, Himawan Halim   +2 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

The patent services of the institutions of higher education — one of the key elements in formation and realization of the government politics of Russian economical rise

Бюллетень сибирской медицины, 2002
The process of formation of a single government politics in the sphere of industrial property is discussed. It is pointed out that economical significance of the objects of IP is rising because of priority orientation of the Russian science and industry ...
N. G. Zubareva
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Delineation of deep-seated crustal structures from magnetic data in the southeastern part of the Niger Delta basin, Nigeria

Frontiers in Earth Science
Regional magnetic data in the southeastern segment of the Nigerian Niger Delta were evaluated with the aim of mapping deep-seated tectonic elements. Enhanced filtering operations and 3D forward modelling were applied on the magnetic data.
Ohara E. Eze, Anthony A. Okiwelu, Stephen E. Ekwok, Kamal Abdelrahman, Hassan Alzahrani, Ubong C. Ben, Amin Ibrahim, Chibuike Akpa, Peter Andráš, Samuel I. Ugar, Ahmed M. Eldosouky   +10 more
doaj   +1 more source

Will the argues between an employee and an employer come to the end?

Бюллетень сибирской медицины, 2002
In the article the question of regulation of the relations between the employer and employers is discussed. With the aim to define these relations there was established, inner Thesis about the office inventions in Siberian State Medical University.
G. D. Tsesarskaya
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Neural processing of audiovisual and painful analogue trauma and its relationship with subsequent audiovisual and pain intrusions

European Journal of Psychotraumatology
Background: Posttraumatic stress disorder and medically unexplained pain frequently co-occur. While pain is common during traumatic events, the processing of pain during trauma and its relation to audiovisual and pain intrusions is poorly understood ...
Stephan F. Miedl, Laila K. Franke, Sarah K. Danböck, Michael Martini, Sabrina Hettegger, Martin Kronbichler, Herta Flor, Frank H. Wilhelm   +7 more
doaj   +1 more source