Results 61 to 70 of about 46,005 (268)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Convergence Results for Invariant Curve Algorithms [PDF]

Mathematics of Computation, 1988
In this paper a convergence result for the algorithm described by Kevrekidis et al. [7] is given. It is shown that this algorithm for the approximation of an invariant curve converges provided the curve is attracting. The approximation error is estimated.
openaire   +2 more sources

θ-CURVE POLYNOMIALS AND FINITE-TYPE INVARIANTS [PDF]

Journal of Knot Theory and Its Ramifications, 2002
The normalized Yamada polynomial, [Formula: see text], is a polynomial invariant in variable A for θ-curves. In this work, we show that the coefficients of [Formula: see text] which is obtained by replacing A with ex = ∑ xn/n! are finite-type invariants for θ-curves although the coefficients of original [Formula: see text] are not finite-type.
Huh, Y, Jin, GT Jin, Gyo Taek
openaire   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Cubic and quartic planar differential systems with exact algebraic limit cycles

Electronic Journal of Differential Equations, 2011
We construct cubic and quartic polynomial planar differential systems with exact limit cycles that are ovals of algebraic real curves of degree four. The result obtained for the cubic case generalizes a proposition of [9].
Ahmed Bendjeddou, Rachid Cheurfa
doaj  

Multi-Component Integrable Systems and Invariant Curve Flows in Certain Geometries

Symmetry, Integrability and Geometry: Methods and Applications, 2013
In this paper, multi-component generalizations to the Camassa-Holm equation, the modified Camassa-Holm equation with cubic nonlinearity are introduced.
Changzheng Qu, Junfeng Song, Ruoxia Yao
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

The Ceresa class and tropical curves of hyperelliptic type

Forum of Mathematics, Sigma
We define a new algebraic invariant of a graph G called the Ceresa–Zharkov class and show that it is trivial if and only if G is of hyperelliptic type, equivalently, G does not have as a minor the complete graph on four vertices or the loop of three ...
Daniel Corey, Wanlin Li
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source