Results 71 to 80 of about 1,050,746 (241)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Curve under construction, 2006

, 2006
Curve begins to take shape, with the Exchange Buildings visible in the background.
Hyde, Colin;
core   +1 more source

An Invariant Geometric Feature for Inter-Subject Lumbar Curve Alignment to Detect Spondylolisthesis

IEEE Access
Spondylolisthesis classification commonly relies on the shift distance (SD) feature. This feature measures the displacement between vertebrae but is sensitive to variations in size and rotational alignment of the vertebrae.
Podchara Klinwichit, Watcharaphong Yookwan, Athita Onuean, Paramate Horkaew, Sornsupha Limchareon, Jun-Su Jang, Suwanna Rasmequan, Krisana Chinnasarn   +7 more
doaj   +1 more source

Robust Image Hashing Using Radon Transform and Invariant Features [PDF]

Radioengineering, 2016
A robust image hashing method based on radon transform and invariant features is proposed for image authentication, image retrieval, and image detection. Specifically, an input image is firstly converted into a counterpart with a normalized size.
Y.L. Liu, G.J. Xin, Y. Xiao
doaj  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

On odd powers of nonnegative polynomials that are not sums of squares

Forum of Mathematics, Sigma
We initiate a systematic study of nonnegative polynomials P such that $P^k$ is not a sum of squares for any odd $k\geq 1$ , calling such P stubborn. We develop a new invariant of a real isolated zero of a nonnegative polynomial in the plane,
Grigoriy Blekherman, Khazhgali Kozhasov, Bruce Reznick   +2 more
doaj   +1 more source

General Helices of AW(k)-Type in the Lie Group

Journal of Applied Mathematics, 2012
We study curves of AW(k)-type in the Lie group G with a bi-invariant metric. Also, we characterize general helices in terms of AW(k)-type curve in the Lie group G.
Dae Won Yoon
doaj   +1 more source

Cm-smoothness of invariant fiber bundles for dynamic equations on measure chains [PDF]

, 2004
We present a new self-contained and rigorous proof of the smoothness of invariant fiber bundles for dynamic equations on measure chains or time scales.
Stefan Siegmund, Pötzsche, Christian, Christian Pötzsche, Siegmund, Stefan, Christian Pötzsche, Stefan Siegmund   +5 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source