Results 61 to 70 of about 1,050,746 (241)
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Multi-Component Integrable Systems and Invariant Curve Flows in Certain Geometries
Symmetry, Integrability and Geometry: Methods and Applications, 2013 In this paper, multi-component generalizations to the Camassa-Holm equation, the modified Camassa-Holm equation with cubic nonlinearity are introduced.
Changzheng Qu, Junfeng Song, Ruoxia Yao
doaj +1 more source
Application of pso for solving problems of invariant comparison of two-dimensional closed curve
Вестник СибАДИ, 2017 The problem of estimating the norm of the distance between the two closed smooth curves for pattern recognition is considered. Diffeomorphic transformation curves based on the model of large deformations is described.
Dmitry Borisovich Abramov +2 more
doaj +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
The Ceresa class and tropical curves of hyperelliptic type
Forum of Mathematics, SigmaWe define a new algebraic invariant of a graph G called the Ceresa–Zharkov class and show that it is trivial if and only if G is of hyperelliptic type, equivalently, G does not have as a minor the complete graph on four vertices or the loop of three ...
Daniel Corey, Wanlin Li
doaj +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Doubling bifurcation of a closed invariant curve in 3D maps
, 2012 The object of the present paper is to give a qualitative description of the bifurcation mechanisms associated with a closed invariant curve in three-dimensional maps, leading to its doubling, not related to a standard doubling of tori.
Iryna Sushko +3 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source