Results 81 to 90 of about 808,928 (286)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Mean Field Approaches to Lattice Gauge Theories: A Review
EntropyDue to their broad applicability, gauge theories (GTs) play a crucial role in various areas of physics, from high-energy physics to condensed matter. Their formulations on lattices, lattice gauge theories (LGTs), can be studied, among many other methods,
Pierpaolo Fontana, Andrea Trombettoni
doaj +1 more source
On Invariant Sets for the Equations of Motion of a Rigid Body in the Hess-Appelrot Case
Известия Иркутского государственного университета: Серия "Математика", 2020 We consider the problem of motion of a rigid body in the Hess-Appelrot case when the equations of motion have three first integrals as well as the invariant manifold of Hess.
V. D. Irtegov, T. N. Titorenko
doaj +1 more source
On the extremality of Hofer's metric on the group of Hamiltonian diffeomorphisms
, 2005 Let M be a closed symplectic manifold, and let | | be a norm on the space of all smooth functions on M, which are zero-mean normalized with respect to the canonical volume form.
Ostrover, Yaron, Wagner, Roy
core +1 more source
Invariant means on locally compact semigroups [PDF]
Proceedings of the American Mathematical Society, 1972 Let G be a locally compact semigroup (jointly continuous semigroup operation), M(G) the algebra of all bounded regular Borel measures on G (with convolution as multiplication), E a separated locally convex space and S a compact convex subset of E. We show that there is a left invariant mean on the space LUC(G) of all bounded left uniformly continuous ...
openaire +2 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Bi-Lipschitz Mappings and Quasinearly Subharmonic Functions
International Journal of Mathematics and Mathematical Sciences, 2010 After considering a variant of the generalized mean value inequality of quasinearly subharmonic functions, we consider certain invariance properties of quasinearly subharmonic functions.
Oleksiy Dovgoshey, Juhani Riihentaus
doaj +1 more source
The round sphere minimizes entropy among closed self-shrinkers [PDF]
, 2012 The entropy of a hypersurface is a geometric invariant that measures complexity and is invariant under rigid motions and dilations. It is given by the supremum over all Gaussian integrals with varying centers and scales.
Colding, Tobias Holck +3 more
core +3 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source