Results 81 to 90 of about 88,430 (310)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

T-duality invariant approaches to string theory

open access: yes, 2010
PhDThis thesis investigates the quantum properties of T-duality invariant formalisms of String Theory. We introduce and review duality invariant formalisms of String Theory including the Doubled Formalism.
Thompson, Daniel C, Thompson, Daniel C.
core  

Scale-covariant and scale-invariant Gaussian derivative networks [Elektronisk resurs]

open access: yes, 2020
This article presents a hybrid approach between scale-space theory and deep learning, where a deep learning architecture is constructed by coupling parameterized scale-space operations in cascade.
Lindeberg, Tony,
core  

Conservation Laws and Invariant Measures in Surjective Cellular Automata [PDF]

open access: yes, 2011
We discuss a close link between two seemingly different topics studied in the cellular automata literature: additive conservation laws and invariant probability measures.
Kari, Jarkko   +7 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Theory of Longitudinal Adiabatic Invariant in the Helical Torus

open access: yes, 1990
"The theory on the longitudinal adiabatic invariant valid for the helical magnetic field is developed on the basis of the variable Transformation from the guiding center variables to the new adiabatic variables.
"Todoroki, J."
core  

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

Robust Positively Invariant Conditions for Perturbed Linear Discrete-Time Systems Using Dual Optimization

open access: yesAxioms
This paper presents both sufficient and necessary conditions for polyhedral sets and symmetric polyhedral sets to be robust positively invariant sets within perturbed linear discrete-time systems.
Hongli Yang   +2 more
doaj   +1 more source

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