Results 81 to 90 of about 808,546 (198)
Cumanayagua en el teatro de luchas coloniales.
Revista Científica Cultura, Comunicación y Desarrollo, 2020 Durante el período colonial cubano se desarrollaron una serie de eventos que propiciaron las causas para el esta - llido de las luchas por la independencia, en las cuales el territorio de Cumanayagua se vio inmerso.
Harold Ariel Pérez Sosa +4 more
doaj
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Sobre Amy S. Greenberg, A Wicked War. Polk, Clay, Lincoln and the 1846 U.S. Invasion of México
Historia Mexicana El Colegio de México, 2014 -
Josefina Zoraida Vázquez
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
La primera Guerra de Chechenia en la pantalla: el prisionero de las montañas (2006)
Historia Actual On-Line, 2012 El cine se ha convertido en uno de los elementos más recurrentes a la hora de establecer historias no oficiales y radiografiar sociedades trastocadas por los diversos conflictos que han ido aflorando en las diversas regiones del mundo. En este caso, este
Igor Barrenetxea Marañón
doaj
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Archivos Latinoamericanos de NutriciónEn Costa Rica, cerca del 25% de la producción de leche nacional es utilizada en la elaboración de queso tierno no pasteurizado, y el consumo de este producto es aproximadamente de 4 a 5 kg anuales per cápita.
Carolina Cháves, María Laura Arias
doaj