Results 51 to 60 of about 811,172 (247)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

A first record of biological soil crusts in the Cape Floristic Region

South African Journal of Science, 2012
To date, the biological soil crusts (BSCs) of southern Africa are thought to be dominated mainly by cyanobacteria, with the exception of the lichen fields of the Namib Desert.
Denise Mager, Cang Hui
doaj  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Reduced MAGI3 level by HPV18E6 contributes to Wnt/β‐catenin signaling activation and cervical cancer progression

FEBS Open Bio, 2021
Human papillomavirus type 18 (HPV18) has high carcinogenic power in invasive cervical cancer (ICC) development. However, the underlying mechanism remains elusive.
Zhuoli Yang, Hua Liu, Ran Song, Wenxiu Lu, Haibo Wang, Siyu Gu, Xuedi Cao, Yibin Chen, Jihuan Liang, Qiong Qin, Xiaomei Yang, Duiping Feng, Junqi He   +12 more
doaj   +1 more source

Invasive neighbors

Blood, 2013
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Paolini, Ambra, Bonacorsi, Goretta
openaire   +3 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

The pet trade of native species outside of their natural distributions within Australia is a biosecurity risk

Conservation Science and Practice
The trade of alien species as pets is increasingly recognized as a biosecurity risk due to their intentional and accidental release into the wild.
Adam Toomes, Oliver C. Stringham, Stephanie Moncayo, Katherine G. W. Hill, Jacob Maher, Freyja Watters, Sebastian Chekunov, Pablo García‐Díaz, Lewis Mitchell, Joshua V. Ross, Phillip Cassey   +10 more
doaj   +1 more source

A new species of the genus Chinattus Logunov, 1999 from Wuyi Mountain National Park, China (Araneae, Salticidae) [PDF]

Biodiversity Data Journal
The genus Chinattus Logunov, 1999, a group of jumping spiders (Salticidae), has been recorded across multiple regions in China. Current records indicate its presence in Anhui, Hunan, Yunnan, Hubei, Taiwan, Guangdong, Hong Kong, Guizhou, Fujian, Chongqing
Xiaoting Lyu, Qiangyong Fan, Zihan Cai, Zhian Zou, Keke Liu, Binlu Liu   +5 more
doaj   +3 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source