Results 81 to 90 of about 6,389,024 (283)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Future scenarios for British biodiversity under climate and land-use change
Nature CommunicationsProjections of biodiversity futures are needed to translate global policies into national action. We use dissimilarity modelling to project climate change scenarios for 1002 plant, 56 butterfly, and 219 bird species across Great Britain up to 2080. Under
Rob Cooke +15 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Endocardial Invasion of Lung Cancer Undiagnosable before Autopsy
Case Reports in Oncology, 2014 A 59-year-old male patient presented with left chest discomfort on admission. His medical history included encephalitis in childhood and his smoking history was 20 cigarettes per day for 40 years.
T. Mizuno +21 more
doaj +1 more source
Zhongliu Fangzhi Yanjiu, 2020 Objective To explore the expression of ZEB1-AS1 in endometrial cancer (EC), and its correlation with clinicopathological features. Methods The expression of ZEB1-AS1 and ZEB1 in 195 pairs of endometrial cancer and paracancerous tissues were detected by ...
SONG Jiao, WANG Li
doaj +1 more source
[History of minimally invasive surgery].
Medicinski pregled, 2010 This paper presents a historical review and development of minimally invasive surgery. The interest of physicians to "look into the internal organs" has existed since the ancient time. The first described endoscopy was by Hippocrates. He made reference to a rectal speculum. The credit for modern endoscopy belongs to Bozzini.
Branka, Radojcić +4 more
openaire +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source