Results 41 to 50 of about 75,411 (309)

Unlocking the Potential of MXene‐Based Electrochemical Biosensors: A Review of Biofunctionalization Strategies and Biosensing Principles

Advanced Materials Technologies, EarlyView.
ABSTRACT Electrochemical biosensors enable the accurate and timely detection of clinical biomarkers, improving healthcare and precision medicine. MXene nanosheets, a class of 2D transition metal carbides, nitrides, and carbonitrides, are promising materials for developing next‐generation electrochemical biosensors due to their unique physicochemical ...
Muhsin Ali, Sharat Chandra Barman, Isobel Steer, Aya H. Alshareef, Dana Alsulaiman   +4 more
wiley   +1 more source

Roles of Vitellogenin and Its Receptor Genes in Female Reproduction of the Cigarette Beetle, Lasioderma serricorne

Insects
Vitellogenin (Vg) and the vitellogenin receptor (VgR) play essential roles in insect reproductive development. However, the functions of Vg and VgR genes in Lasioderma serricorne, an important insect pest of stored products, are unknown.
Qian Guo, Mingxun Zu, Deqian Liu, Yi Yan, Wenjia Yang, Kangkang Xu   +5 more
doaj   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

The impact of invasive alien species on the forage and pasture genetic resource diversity in the pastoral area of Afar National Regional State, Northeastern of Ethiopia. [PDF]

, 2018
Prosopisjuliflora is one of the most invasive species in arid areas of Afar region and protected area of Awash national park. The invasion of P. julifloraincreased at alarming rate devastating forage and pasture abundance and diversity that makes ...
Angassa, D. (Delessa)
core  

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that precedes the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Using information technology, communication and citizen science in alien invasive plant management in Kruger National Park, South Africa [PDF]

, 2016
Invasive plant species are a major threat to the biodiversity of protected areas and South Africa's Kruger National Park (KNP), which covers about 20 000 km2, is no exception.
Carrara, Alain, Foxcroft, Llewellyn C., Grard, Pierre, Guezou, Anne, Le Bourgeois, Thomas, Marshall, Thembisile, Taylor, Robert W., Thompson, Dave I.   +7 more
core  

IPBES Invasive Alien Species Assessment: Factsheet 5 - Invasive alien species management and governance

, 2023
Factsheet 5 - Invasive alien species management and governance Messages from the Summary for Policymaters of the Thematic Assessment Report on Invasive Alien Species and their Control of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) specifically for invasive alien species management and governance.
Roy, Helen E., Pauchard, Aníbal, Stoett, Peter, Renard Truong, Tanara   +3 more
openaire   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Etiology, Biological Characteristics, and Fungicide Sensitivity of Bipolaris sorokiniana Causing Root Rot in Wild Orchardgrass (Dactylis glomerata L.)

Agronomy
Dactylis glomerata is a globally important cool-season forage grass with high ecological and economic value. During field surveys conducted in three counties of the Ili region of Xinjiang, Zhaosu County, Tekes County, and Xinyuan County, a previously ...
Lei Shan, Zhenyu Yang, Sen Sun, Benzhong Fu, Lili Wang   +4 more
doaj   +1 more source