Results 91 to 100 of about 577,114 (263)

A conserved fungal morphogenetic kinase regulates pathogenic growth in response to carbon source diversity

open access: yesNature Communications
Fungal pathogens must exhibit strong nutritional plasticity, effectively sensing and utilizing diverse nutrients to support virulence. How the signals generated by nutritional sensing are efficiently translated to the morphogenetic machinery for optimal ...
Adela Martin-Vicente   +7 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Growth parameters of the invasive gastropod Melanoides tuberculata (Müller, 1774) (Gastropoda, Thiaridae) in a semi-arid region, Northeastern Brazil

open access: yesActa Scientiarum: Biological Sciences, 2019
Melanoides tuberculata has invaded several aquatic ecosystems in the Neotropical region. This species shows high adaptive capacity and plasticity, establishing itself in several basins, promoting negative impacts on environments and native species. Here,
Cicero Diogo Lins Oliveira   +1 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

Allelopathic effects of invasive weed species Abutilon theophrasti Medik., Ambrosia artemisiifolia L., Datura stramonium L. and Xanthium strumarium L. on tomato [PDF]

open access: yesPesticidi i Fitomedicina, 2019
Abutilon theophrasti Medik, Ambrosia artemisiifolia L., Datura stramonium L. and Xanthium strumarium L. are four well-known invasive weed species that are widespread in many crops.
Radivojević Ljiljana   +3 more
doaj  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

MET Oncogene Controls Invasive Growth by Coupling with NMDA Receptor. [PDF]

open access: yesCancers (Basel), 2022
Gallo S   +3 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Sonographic Brain Volume Growth Trajectories in VLBW and Clinical Determinants—Data from the NeoNEVS Project

open access: yesChildren
Background: Very Low Birth Weight preterm infants are at elevated risk for disrupted brain growth and later neurodevelopmental impairment. Bedside-accessible tools for monitoring cerebral development remain limited.
Christian Brickmann   +6 more
doaj   +1 more source

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