Results 101 to 110 of about 577,114 (263)

CHRM3 is a novel prognostic factor of poor prognosis and promotes glioblastoma progression via activation of oncogenic invasive growth factors. [PDF]

Oncol Res, 2023
Zhang B, Zhao J, Wang Y, Xu H, Gao BO, Zhang G, Han B, Song G, Zhang J, Meng W.   +9 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Germination patterns and seedling growth of congeneric native and invasive Mimosa species: Implications for risk assessment

Ecology and Evolution
Comparisons of plant traits between native and invasive congeners are useful approaches for identifying characteristics that promote invasiveness. We compared germination patterns and seedling growth of locally sympatric populations of native Mimosa ...
Nisha Kharel, Anuj Dangol, Ashmita Shrestha, Hemanti Airi, Anjana Devkota, Lal Bahadur Thapa, Bharat Babu Shrestha   +6 more
doaj   +1 more source

The short-chain fatty acid crotonate reduces invasive growth and immune escape of <i>Candida albicans</i> by regulating hyphal gene expression. [PDF]

mBio, 2023
McCrory C, Verma J, Tucey TM, Turner R, Weerasinghe H, Beilharz TH, Traven A.   +6 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Distinct Roles of Ena ATP Family Proteins in Sodium Accumulation, Invasive Growth, and Full Virulence in <i>Colletotrichum gloeosporioides</i>. [PDF]

J Fungi (Basel), 2023
Deng TC, Yang JY, Sun ML, Zhang YZ, Pan YT, Huang L.   +5 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Invasive Growth of Ailanthus altissima Trees is Associated with a High Rate of Sensitization in Atopic Patients. [PDF]

J Asthma Allergy, 2022
Prenzel F, Treudler R, Lipek T, Vom Hove M, Kage P, Kuhs S, Kaiser T, Bastl M, Bumberger J, Genuneit J, Hornick T, Klotz S, Zarnowski J, Boege M, Zebralla V, Simon JC, Dunker S.   +16 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Arbuscular mycorrhiza increases the facilitation between adult plant and seedling but root‐knot nematode inhibits it

Ecosphere
Soil biotic and abiotic factors can affect the interaction between invasive and native species. However, it is not yet clear how arbuscular mycorrhizal (AM) symbiosis affects the interaction between adult invasive plants and neighboring seedlings.
Lei Wang, Xuhang Zhou, Zhanhui Tang
doaj   +1 more source