Results 111 to 120 of about 6,603,549 (290)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Hemangioma of the hard palate with invasive growth into the maxillary sinus. [PDF]

Clin Case Rep, 2022
Lobekk OK, Pedersen TØ.
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Invasive Species Impacts on Infrastructure [PDF]

, 2016
Executive Summary Invasive species represent one of the most significant threats to ecosystems, human and animal health, infrastructure, the economy, and cultural resources.
Invasive Species Advisory Committee
core  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

MET Oncogene Controls Invasive Growth by Coupling with NMDA Receptor. [PDF]

Cancers (Basel), 2022
Gallo S, Vitacolonna A, Comoglio P, Crepaldi T.   +3 more
europepmc   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Sonographic Brain Volume Growth Trajectories in VLBW and Clinical Determinants—Data from the NeoNEVS Project

Children
Background: Very Low Birth Weight preterm infants are at elevated risk for disrupted brain growth and later neurodevelopmental impairment. Bedside-accessible tools for monitoring cerebral development remain limited.
Christian Brickmann, Renée Lampe, Irina Sidorenko, Nils Gauger, Julia Hauer, Marcus Krüger, Simon Loth   +6 more
doaj   +1 more source

Allelopathic effects of invasive weed species Abutilon theophrasti Medik., Ambrosia artemisiifolia L., Datura stramonium L. and Xanthium strumarium L. on tomato [PDF]

Pesticidi i Fitomedicina, 2019
Abutilon theophrasti Medik, Ambrosia artemisiifolia L., Datura stramonium L. and Xanthium strumarium L. are four well-known invasive weed species that are widespread in many crops.
Radivojević Ljiljana, Sarić-Krsmanović Marija, Gajić-Umiljendić Jelena, Šantrić Ljiljana   +3 more
doaj  

CHRM3 is a novel prognostic factor of poor prognosis and promotes glioblastoma progression via activation of oncogenic invasive growth factors. [PDF]

Oncol Res, 2023
Zhang B, Zhao J, Wang Y, Xu H, Gao BO, Zhang G, Han B, Song G, Zhang J, Meng W.   +9 more
europepmc   +1 more source