Results 91 to 100 of about 10,113 (218)

Personalized Models of Biological Barriers and Their Diseases: Recent Progress with Organs‐On‐Chips

Advanced Biology, Volume 10, Issue 2, February 2026.
Buck and Bugter et al. explore the architectural diversity and physiological functions of human barrier systems and reveal how organ‐on‐chip platforms, particularly those integrating patient‐derived cells, are advancing barrier disease modeling. They highlight how emerging biological and technological advances can be used to bridge the gap between ...
Franziska Buck, Jeroen Bugter, Gizem Yorukoglu, Mina Kazemzadeh Dastjerd, Thomas E. Winkler   +4 more
wiley   +1 more source

Meningococcal Serogroup Y Meningitis Reveals Inborn Factor B Deficiency

European Journal of Immunology, Volume 56, Issue 2, February 2026.
We report a novel case of complete complement Factor B deficiency revealed by invasive meningococcal disease. Using combined functional and genetic analyses, we demonstrate that loss of Factor B abolishes alternative pathway activity despite detectable protein levels. These findings provide a mechanistic framework relevant to complement diagnostics and
Camille Bougeard, Eléonore Eskander, Paula Vieira Martins, Joan Bitan, Julia Roquigny, Christèle Kyheng, Tamazoust Guiddir, Véronique Frémeaux‐Bacchi, Cécile Gonnin, Carine ElSissy   +9 more
wiley   +1 more source

The Complement System in ANCA‐Associated Vasculitis: Mechanistic Insights, Therapeutic Horizons, and Unmet Clinical Needs

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
Complement activation, particularly via the alternative pathway, drives inflammation and organ damage in ANCA‐associated vasculitis. This review highlights mechanistic insights, tissue and biomarker evidence, and clinical implications of targeting the C5a–C5aR1 axis.
Kehinde Sunmboye, Pauline Millan
wiley   +1 more source

Risk and protective factors for meningococcal disease in adolescents: matched cohort study

, 2006
Objective: To examine biological and social risk factors for meningococcal disease in adolescents. Design: Prospective, population based, matched cohort study with controls matched for age and sex in 1:1 matching.
Stuart, J.M., Kaczmarski, E., Tully, J., Coen, P.G., Klein, N., Peckham, C., Viner, R.M., Zambon, M., Booth, C., Booy, R.   +9 more
core  

Brain Abscesses Complicating Bacterial Meningitis—A Nationwide Cohort Study From the Netherlands

European Journal of Neurology, Volume 33, Issue 2, February 2026.
Prevalence, pathogen distribution, clinical characteristics, and outcomes of brain abscess in bacterial meningitis was assessed in this study. ABSTRACT Background Brain abscesses rarely complicate bacterial meningitis while their clinical characteristics and outcomes have not been systematically assessed.
Fabian D. Liechti, Evelien H. G. M. Drost, Merijn W. Bijlsma, Matthijs C. Brouwer, Diederik van de Beek   +4 more
wiley   +1 more source

The important lessons lurking in the history of meningococcal epidemiology

Expert Review of Vaccines
Introduction The epidemiology of invasive meningococcal disease (IMD), a rare but potentially fatal illness, is typically described as unpredictable and subject to sporadic outbreaks.Areas covered Meningococcal epidemiology and vaccine use during the ...
Ray Borrow, Jamie Findlow
doaj   +1 more source

Fatal meningococcal meningitis in a HIV-infected patient caused by serogroup C Neisseria meningitidis belonging to the non-hypervirulent clonal complex ST-60 (cc60)

Brazilian Journal of Infectious Diseases, 2011
Meningococcal strains belonging to clonal complex cc60 are not associated with hypervirulent lineages and were never reported as causing disease in Latin American countries.
Claudia Ferreira de Andrade, Biologist, Denise Cotrim da Cunha, MD, Veronica Cavalcanti, Biologist, Ivano de Filippis   +3 more
doaj   +1 more source

Deficiency of the eighth component of complement associated with recurrent meningococcal meningitis: case report and literature review

Brazilian Journal of Infectious Diseases
The authors report a case of deficiency of the eighth component of complement in a young adult with a history of three episodes of meningitis; one of them proved to be meningococcal.
Daniela Dornelles Rosa, Alessandro C. Pasqualotto, Maurício de Quadros, Sérgio Henrique Prezzi   +3 more
doaj   +1 more source

Invasive meningococcal disease: Which vaccines protect against it?

, 2018
Invasive meningococcal disease is a rare, but life-threatening cause of meningitis and septicaemia. Karen Ford describes the disease and causative bacteria, and provides a summary of the vaccines used to prevent it Invasive meningococcal disease is a ...
Karen J Ford
core   +1 more source

Emergence of serogroup C meningococcal disease associated with a high mortality rate in Hefei, China

BMC Infectious Diseases, 2012
Background Neisseria meningitidis serogroup C has emerged as a cause of epidemic disease in Hefei. The establishment of serogroup C as the predominant cause of endemic disease has not been described.
Xu Xi-Hai, Ye Ying, Hu Li-Fen, Jin Yu-Hui, Jiang Qin-Qin, Li Jia-Bin   +5 more
doaj   +1 more source