Results 101 to 110 of about 234,043 (300)

Early Radiation Therapy Response Assessment Using Multi‐Scale Photoacoustic Imaging

Advanced Science, EarlyView.
Tomographic and mesoscopic photoacoustics capture intratumoural features of radioresistance and response. ABSTRACT There is a critical unmet clinical need to identify biomarkers that predict and detect radiation therapy (RT) response in cancer. Using the unique capabilities of multi‐scale photoacoustic imaging (PAI) to depict tumor oxygenation and ...
Thierry L. Lefebvre, Mariam‐Eleni Oraiopoulou, Ellie V. Bunce, Thomas R. Else, Lorna C. Wright, Monika A. Golinska, Lina Hacker, Cara Brodie, Steven Kupczak, Yi Cheng, Lisa Young, Paul W. Sweeney, Sarah E. Bohndiek   +12 more
wiley   +1 more source

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

Editorial: Pediatric Long-Term Non-invasive Ventilation

Frontiers in Pediatrics, 2021
Brigitte Fauroux, Renato Cutrera
doaj   +1 more source

Acute respiratory failure in patients with hematological malignancies : outcomes according to initial ventilation strategy : a Groupe de recherche respiratoire en réanimation onco-hématologique (Grrr-OH) study [PDF]

, 2015
Background: In patients with hematological malignancies and acute respiratory failure (ARF), noninvasive ventilation was associated with a decreased mortality in older studies. However, mortality of intubated patients decreased in the last years. In this
Azoulay, Elie, Benoit, Dominique, Bruneel, Fabrice, Chevret, Sylvie, Kouatchet, Achille, Lebert, Christine, Lemiale, Virginie, Meert, Anne-Pascale, Mokart, Djamel, Nyunga, Martine, Perez, Pierre, Pène, Frederic, Rabbat, Antoine, Resche-Rigon, Matthieu, Vincent, François   +14 more
core   +2 more sources

Redefining Dendritic Cell Vaccines: Synergistically Co‐priming DC and B Cells With Nanoparticles Loading Whole Cell Antigens Maximizes the Efficacy of DC Vaccines

Advanced Science, EarlyView.
Dendritic cells (DC) vaccine is an important type of vaccines. However, the limited efficacy of DC vaccines hinders their widely application. This study redefines DC vaccines and provides a new DC‐BC vaccine that have much better therapeutic efficacy.
Xiangxiang Xu, Xianlan Chen, Jin Wang, Yuhan Liu, Sidra Mustafa, Lu Diao, Rongrong Zhao, Haiyang Chi, Kang Hu, Jiashan Zhu, Jun Zhao, Mi Liu   +11 more
wiley   +1 more source

Perspectives on prolonged nocturnal invasive mechanical ventilation

Journal of Mechanical Ventilation
The utilization of invasive mechanical ventilation (IMV) has become common practice for a large and expanding number of patients with chronic respiratory failure resultant from several medical diseases and disorders. Although protocols and guidelines for
Robert L Vender
doaj   +1 more source

Minimally Invasive Mitral Valve Surgery II: Surgical Technique and Postoperative Management. [PDF]

, 2016
Techniques for minimally invasive mitral valve repair and replacement continue to evolve. This expert opinion, the second of a 3-part series, outlines current best practices for nonrobotic, minimally invasive mitral valve procedures, and for ...
Agnihotri, Arvind K, Ailawadi, Gorav, Barnhart, Glenn R, Farivar, R Saeid, Fayers, Trevor M, Goldman, Scott M, Grossi, Eugene A, Guy, T Sloane, Hargrove, W Clark, Hummel, Brian W, Khan, Junaid H, Lehr, Eric J, Lewis, Clifton TP, Malaisrie, S Chris, Mehall, John R, Moront, Michael G, Murphy, Douglas A, Rodriguez, Evelio, Ryan, William H, Salemi, Arash, Segurola, Romualdo J, Shemin, Richard J, Smith, J Michael, Smith, Robert L, Weldner, Paul W, Wolfe, J Alan   +25 more
core   +1 more source

Single‐Cell Metabolic Imaging and Digital Scoring of Fat Tissue Remodeling by Label‐Free Metabolic Microscopy

Advanced Science, EarlyView.
Mid‐infrared optoacoustic microscopy (MiROM) acquires lipid‐ and protein‐ associated vibrational contrast in intact fat tissue without dyes, preserving native tissue architecture. Through lateral and axial segmentation, MiROM tracks intrinsic intracellular changes during postnatal remodeling. A quantitative spatial analysis tool (Q‐SAT) maps white‐ and
Myeongseop Kim, Constantin Berger, Alexander Wolf, Alina Peteranderl, Martin Klingenspor, Vasilis Ntziachristos, Yongguo Li, Miguel A. Pleitez   +7 more
wiley   +1 more source

A Reinforcement Learning Approach to Weaning of Mechanical Ventilation in Intensive Care Units

, 2017
The management of invasive mechanical ventilation, and the regulation of sedation and analgesia during ventilation, constitutes a major part of the care of patients admitted to intensive care units. Both prolonged dependence on mechanical ventilation and
Cheng, Li-Fang, Chivers, Corey, Draugelis, Michael, Engelhardt, Barbara E, Prasad, Niranjani   +4 more
core  

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

Advanced Science, EarlyView.
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang, Tingting Qu, Qibing Sun, Ran Li, Junfei Dong, Yuming Du, Ziyin Xuan, Lei Wang, Hanli Li, Jianyun Sun, Fangliang Chen, Jinshuai Liu, Zifan Yang, Jianxiang Lei, Qian Yang, Bin Wang, Zhiming Zhou, Yu Wang   +17 more
wiley   +1 more source