Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Needs-Based Innovation in Cardiovascular Medicine
JACC: Basic to Translational Science, 2016 More than a decade ago, a formalized fellowship training program in medical device innovation, the first of its kind, was created at Stanford University.
Jonathan G. Schwartz, MD +4 more
doaj +1 more source
Selling the Sights: The Invention of the Tourist in American Culture. By Will B. Mackintosh. New York: NYU Press, 2019. 272 pp. Illustrations, notes, index. Hardcover, $35.00. ISBN: 978-1-4798-8937-2. [PDF]
, 2022 Henry Knight Lozano
openalex +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Institutionalized Incentives for Ingenuity - Patent Value and the German Employees’ Inventions Act [PDF]
, 2006 Dietmar Harhoff, Karin Hoisl
openalex +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
The Invention of the Printing Press: Changing Legal Culture in England [PDF]
, 2017 Niels Pepels
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Dynamic resource allocation scheme for distributed heterogeneous computer systems [PDF]
, 1991 This invention relates to a resource allocation in computer systems, and more particularly, to a method and associated apparatus for shortening response time and improving efficiency of a heterogeneous distributed networked computer system by ...
Liu, Howard T., Silvester, John A.
core +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Incentives and Invention in Universities [PDF]
We show that economic incentives affect the number and commercial value of inventions generated in universities. Using panel data for 102 U.S. universities during the period 1991-1999, we find that universities which give higher royalty shares to ...
Mark Schankerman, Saul Lach
core +3 more sources