Results 71 to 80 of about 790,747 (335)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Advances in the Molecular Mechanisms of Resistance in Chilo suppressalis

Insects
The rice stem borer, Chilo suppressalis (Walker) (Lepidoptera: Crambidae), is one of the major pests in rice-growing areas. Its larvae feed on rice stems, causing symptoms of rice dead sheaths, dead hearts, and withered ears, resulting in heavy rice ...
Wenchao Ge, Guanghang Chen, Mengzhen Wang, Shunfan Wu, Congfen Gao   +4 more
doaj   +1 more source

Le travail discipliné : genèse d’un projet technologique au xixe siècle

Cahiers d’histoire, 2009
Face à l’effritement des anciennes régulations du travail, les économistes et les fabricants du début du xixe siècle s’efforcent de trouver des moyens pour lutter contre « l’oppression du travail » et discipliner la main-d’œuvre qui inquiète à l’ère des ...
François Jarrige
doaj   +1 more source

Content-related solution quality in invention activities and worked solutions – promoting the professional vision of classroom management

, 2022
Sonja Wedde, Annette Busse, Dorit Bosse
openalex   +2 more sources

Students Engineer Solution to Public Health Issue in Dominican Republic [PDF]

, 2016
Student chapter of Engineers Without Borders dispatches to rural village to build invention that replaces open-fire ...
Rodrigues, Jill
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Searching for Ways to Improve for Calculation Method of Employer’s Profit as a Factor for Calculating Employee Invention Remuneration: Focused on Hypothetical Royalty Rate, Exclusivity Contribution Rate, Employee Invention’s Contribution Rate

Journal of Intellectual Property
Supreme Court decision 2017Hu1304 has established an inherency doctrine in determining novelty. According to the decision, it is not enough to simply show the possibility or probability that something can be done to show prior art to be the same as the ...
Joohwan Lee
doaj   +1 more source

Sur les origines du concept de méthode à l’âge classique : La Ramée, Bacon et Descartes

Revue LISA, 2014
Our contemporary concept of method, as a formal discourse that comes before science itself and aims at directing scientific inquiry, prescribing several steps and checking-procedures, is not the concept of method that was familiar to educated 17th ...
Philippe Hamou
doaj   +1 more source

Extruder for food product (otak–otak) with heater and roll cutter [PDF]

, 2017
Food extrusion is a form of extrusion used in food industries. It is a process by which a set of mixed ingredients are forced through an opening in a perforated plate or die with a design specific to the food, and is then cut to a specified size by ...
Abd. Manan, Abdul Shukur, Ahmad, Muhamad Nurhisham, Baharom, Muhamad Hafizuddin, Che Mat, Nor Ain, Dol Baharin, Muhammad Zulhusmi, Hassan, Mohd Fahrul   +5 more
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source