Results 101 to 110 of about 334,849 (335)

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

open access: yesMolecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton   +17 more
wiley   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

open access: yesMolecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop   +10 more
wiley   +1 more source

Management of innovative activity under economic and financial changes [PDF]

open access: yes
In modern conditions, one of the main tasks of innovative activity’s efficiency is to develop a new concept of innovative processes' management.
Nazarova, Rano
core   +1 more source

An analysis of influence of methods of calculations is on the got result [PDF]

open access: yes, 2014
В статті здійснюється порівняння результатів типових розрахунків вала, виконаних з використанням різних методик,розрахункових схем, способів прикладення навантаження (на прикладі крутного моменту, що передається валом). Розглядаються результати, одержані
Danylenko, O. V.   +1 more
core  

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

open access: yesMolecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho   +11 more
wiley   +1 more source

The improvement of Inventor Studio at 3D modelling, visualization and animation [PDF]

open access: yes, 2011
V této práci je popsán současný stav moderních animačních a vizualizačních programů. Je zde vysvětlena filozofie adaptivního parametrického modelování a předveden postup tvorby modelu sestavy s adaptivními vazbami v programu Autodesk Inventor 2010.
Trödler, Michal
core  

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

The Inventor of the Lightning Rod [PDF]

open access: green, 1893
Joseph J. Kral
openalex   +1 more source

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