Results 81 to 90 of about 285,779 (275)
International Harmonization of Patent Law: A Proposed Solution to the United States\u27 First-to-File Debate [PDF]
, 1992 As trade barriers diminish and global economies continue to expand, harmonization and enforcement of international patent protection becomes increasingly important. This note compares the U.S. system with other countries. It argues that the U.S. should
DeBari, Vito J.
core +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Prolific inventors: who are they and where do they locate? Evidence from a five countries US patenting data se [PDF]
The prolific (serial) inventors set up the core of the paper. Prolific inventors tend to have a high productivity in terms of inventions (patents) having in general more economic value.
Alexandre Cabagnols +2 more
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Community structure in co-inventor networks affects time to first citation for patents
Applied Network Science, 2019 We have investigated community structure in the co-inventor network of a given cohort of patents and related this structure to the dynamics of how these patents acquire their first citation.
William Doonan +3 more
doaj +1 more source
Patent Reform and Best Mode: A Signal to the Patent Office or a Step Toward Elimination? [PDF]
, 2012 On September 16, 2011, President Obama signed the America Invents Act (AIA), the first major overhaul of the patent system in nearly sixty years. This article analyzes the recent change to patent law\u27s best mode requirement under the AIA.
Vacca, Ryan G.
core +2 more sources
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
The Meaning of Patent Citations: Report on the NBER/Case-Western Reserve Survey of Patentees [PDF]
A survey of recent patentees was conducted to elicit their perceptions regarding the importance of their inventions, the extent of their communication with other inventors, and the relationship of both importance and communication to observed patent ...
Adam B. Jaffe +2 more
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source