Results 71 to 80 of about 48,027 (244)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
交大法學評論近年來，研發人員使用人工智慧來輔助進行研發新技術已漸漸成為趨勢。因此美國專利商標局訂定了「人工智慧輔助發明的發明人指南」，列出五個指導原則，讓申請人可以更加瞭解人工智慧輔助發明申請案的相關規定。另外，指南明確指出人工智慧輔助發明的申請案中，自然人必須要有對發明有重大的貢獻才可以列名發明人。需要注意的，若人工智慧輔助發明的申請案中，沒有自然人列名為發明人，美國專利商標局可以拒絕該申請案。但由於指南沒有明文要求揭露專利說明書哪個部分是人工智慧的產出，哪個部分是自然人的貢獻，本文認為未來會造成許多法律爭議 ...
劉育彬 Yu-Pin Liu
doaj
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
East Asian Economic Review, 2019 This study investigates the effect of high-skilled inventor emigration rate on growth rate of the country of origin (COO). Inventor emigrants represent the human capital that can generate highly innovative work.
Jisong Kim, Nah Youn Lee
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Profile and influence of the successful fisher-Inventor of marine conservation technology
Conservation & Society, 2010 Anecdotally it is often said that fishers are the best inventors of marine conservation technologies. In this paper I describe case studies of Turtle Excluder Devices (TEDs) and dolphin conservation technology, offering empirical evidence that fishers ...
Jenkins Lekelia
doaj
Cancer Cell InternationalTheranostics is a way of treating illness that blends medicine with testing. Specific characteristics should be present in the best theranostic agents for cancer: (1) the drugs should be safe and non-toxic; (2) they should be able to treat cancer ...
Hannaneh Azimizonuzi +7 more
doaj +1 more source