Results 61 to 70 of about 285,779 (275)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Poljarnyj Vestnik: Norwegian Journal of Slavic Studies, 2001 This paper is an attempt to account for the following kind of para- phrasability: Edison invented the electric bulb - Edison was the inventor of the electric bulb. The proposal is that in the last sentence the holder of the first actant position has been
Lennart Lönngren
doaj +1 more source
"Interregional mobility, productivity and the value of patents for prolific inventors in France, Germany and the U.K" [PDF]
Regional creative resources include inventors. Policies conducive to inventors’ productivity or attracting productive inventors promote regional development.
Christian Le Bas +3 more
core
Water, air and fire at work in Hero's machines [PDF]
, 2011 Known as the Michanikos, Hero of Alexandria is considered the inventor of the world's first steam engine and of many other sophisticated devices. Here we discuss three of them as described in his book "Pneumatica". These machines, working with water, air
Sparavigna, Amelia Carolina
core +1 more source
Harvesting the uncollected fruits of other people’s intellectual labour [PDF]
, 2017 Intellectual property regimes necessarily create artificial scarcity leading to wastage, both by blocking follow-up research and hindering access to those who are only able to pay less then the actual retail price.
Timmermann, Cristian
core +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Hicrî I. Asırda Hadis Uydurma Faaliyeti ve Hadis Uyduranların Tespiti
Türkiye Din Eğitimi Araştırmaları Dergisi, 2020 Hadis tarihinde çokça tartışılan konulardan birisi de hadis uydurma faaliyetinin başlangıcıdır. Tüm görüşlerin ortak noktası ise hicrî birinci asırda birleşiyor olmalarıdır.
Recep Emin Gül
doaj
Inventor mobility index : a method to disambiguate inventor careers [PDF]
, 2017 Usually patent data does not contain any unique identifiers for the patenting assignees or the inventors, as the main tasks of patent authorities is the examination of applications and the administration of the patent documents as public contracts and ...
Doherr, Thorsten
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source