Results 41 to 50 of about 285,779 (275)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Becoming an inventor: a young Latina’s narrative

Frontiers in Education
Latinas, along with many other minoritized groups, are underrepresented as inventors in the United States. Despite accounting for over 9% of the population, <1% of U.S. patent holders are Latina.
Cristina Sáenz, Audra Skukauskaitė, Michelle Sullivan   +2 more
doaj   +1 more source

Application of the Autodesk Inventor Application to Improve Technical Drawing Competence for Class XII Students of SMK Ma'arif Nu 01 Suradadi Department of Automotive Engineering (TKR)

Dinamisia, 2023
Pendidikan dan Penelitian serta Pengabdian merupakan Tridharma perguruan tinggi. Salah satu yang menjadi kewajiban adalah melaksanakan Pengabdian kepada Masyarakat, yang dilakukan dalam kaitannya dengan kepentingan masing-masing lembaga pendidikan ...
faqihfatkhurrozak faqih fatkhurrozak, Firman Lukman Sanjaya, Nur Aidi Ariyanto, Syarifudin Syarifudin, Andre Budhi Hendrawan   +4 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Hercule Florence et « l’art d’inventer »

Photographica
This article analyzes the thought and practice of Hercules Florence through the notion of “the art of inventing”. An entry into the journey of Florence through what inventing meant in the 19th century allows us to rethink the study of the pioneers of ...
Maria Inez Turazzi
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

In vitro membrane binding and protein binding (IAM MB/PB technology) to estimate in vivo distribution: applications in early drug discovery

ADMET and DMPK, 2017
The drug discovery process can be accelerated by chromatographic profiling of the analogs to model in vivo distribution and the major non-specific binding.
Klara Livia Valko, Simon P. Teague, Charles Pidgeon   +2 more
doaj   +1 more source

Penggunaan Mit App Inventor untuk Merancang Aplikasi Pembelajaran Berbasis Android

E-Dimas, 2021
Adopsi penggunaan teknologi dalam pembelajaran dewasa ini semakin meningkat. Teknologi bisa menjadi alat bagi guru untuk menyampaikan materi pembelajaran dengan mudah, menarik dan menyenangkan bagi peserta didik.
Sofia Edriati, Liza Husnita, Erismar Amri, Ami Anggraini Samudra, Nofrian Kamil   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Evaluation of a Three-Phase Bidirectional Isolated DC-DC Converter with Varying Transformer Configurations Using Phase-Shift Modulation and Burst-Mode Switching

Energies, 2020
This paper presents the performance of a three-phase bidirectional isolated DC-DC converter (3P-BIDC) in wye-wye (Yy), wye-delta (Yd), delta-wye (Dy), and delta-delta (Dd) transformer configurations, using enhanced switching strategy that combines phase ...
Nuraina Syahira Mohd Sharifuddin, Nadia M. L. Tan, Hirofumi Akagi   +2 more
doaj   +1 more source