Results 161 to 170 of about 8,047 (306)

NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity

Advanced Science, EarlyView.
Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li, Xin‐Yuan Zhao, Min Zhang, Zhuang‐Feng Weng, Xiao‐Ran Guo, Ying‐Fang Liu, Qiao‐Ping Wang, Huan‐Huan Liang   +7 more
wiley   +1 more source

A Wireless 3D Magneto‐Mechanical Stimulation Platform Drives In Situ Chondrogenic Commitment of Endogenous MSCs

Advanced Science, EarlyView.
An intracellular magneto‐mechanical platform utilizing MSC‐targeted nanomotors is developed. After intra‐articular delivery, these nanomotors target endogenous BMSCs and are actuated within lysosomes to execute trans‐planar rotational‐bouncing motions under a rotating‐fluctuating 3D magnetic field, generating amplified mechanical stimulation.
Zhenguang Li, Li Peng, Laiya Lu, Yingying Wang, Xiaolei Chen, Feng Yin, Cuijun Deng, Yu Cheng   +7 more
wiley   +1 more source

Quality of Life and Mental Health Among Families Caring for Children with Medical Complexity: A Scoping Review. [PDF]

Healthcare (Basel)
Suárez-Carrasco A, León-Campos Á, Peláez-Cantero MJ, García-Mayor S, Pérez-Ardanaz B.   +4 more
europepmc   +1 more source

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

Amazonian Fungal Diversity and the Potential of Basidiomycetes as Sources of Novel Antimicrobials. [PDF]

Biology (Basel)
Dos Santos LCRM, de Almeida JDR, de Sousa NSO, Fernandes FDS, Ennes JFV, Frickmann H, de Souza JVB, de Souza ÉS.   +7 more
europepmc   +1 more source

Comparison through a prospective and randomized study of two replenishment methods at polyvalent hospitalization units with two-bin storage systems

, 2017
Two-bin storage systems increase nursing staff satisfaction and decrease inventories, but the implications that logistic staff would determine the needs of replenishment are unknown.
Baena Lázaro, Pedro Pablo, Sebastián Viana, Tomás, Bernal, Jose L., Mera-Flores, Ana María   +3 more
core  

FOS3D: A Fluorescence‐Enabled Toolkit for Characterizing a Three‐dimensional Osteosarcoma Model

Advanced Science, EarlyView.
FOS3D describes fluorescent (F) osteosarcoma (OS) cells in a tri‐dimensional (3D) model. The study comprises three phases: development, where biofabrication parameters are tuned to achieve cytocompatibility and tumor‐specific mechanical properties in cell‐laden gelatin methacryloyl constructs; validation, where whole‐well fluorescence reading is ...
William Humble, Wiktor Zywicki, Enrico Lucarelli, Ania Naila Guerrieri, Francesca Taraballi, Gianluca Cidonio, Claudia Di Bella, Carmine Onofrillo, Andrea J. O'Connor, Serena Duchi   +9 more
wiley   +1 more source

Circulating Amino Acid Network Remodeling Reveals Systemic Metabolic Reprogramming Predictive of Colorectal Cancer Recurrence and Metastasis

Advanced Science, EarlyView.
Blood‐based amino acid patterns measured by 19F NMR reveal hidden metabolic changes in colorectal cancer. By analyzing how these amino acids interact as a network, machine learning models identify patients at higher risk of recurrence and metastasis.
Ji‐Yeon Lee, Jumi Kim, Taehan Yoon, So Hyun Kwon, Su Chan Park, Dohyun Chun, Dohyeong Kim, Eun Jung Park, Hyunwoo Kim, Ji Min Lee   +9 more
wiley   +1 more source

Expanded Hepatic Progenitor Cells Featured with Aggregation of α‐Synuclein Contribute to Pathologic Bile Duct Regeneration in Biliary Atresia

Advanced Science, EarlyView.
Expanded NCAM1+EpCAM+ hepatic progenitor cells in biliary atresia are characterized by aggregation of α‐synuclein. This pathological protein potentiates cellular susceptibility to GSH‐dependent redox dyshomeostasis, induces unstable biliary cell fate specification, and subsequently drives aberrant biliary regeneration.
Hua Xie, Mengyan Zhu, Zhongxian Zhu, Jiaqi Tang, Ruyi Zhang, Zequan Ding, Junzhi Li, Zhongluan Wu, Paul Kwong Hang Tam, Qianghu Wang, Vincent Chi Hang Lui, Yankai Xia, Weibing Tang   +12 more
wiley   +1 more source

Linking Symptom Inventories Using Semantic Textual Similarity. [PDF]

J Neurotrauma
Kennedy E, Vadlamani S, Lindsey HM, Peterson KS, Dams O'Connor K, Agarwal R, Amiri HH, Andersen RK, Babikian T, Baron DA, Bigler ED, Caeyenberghs K, Delano-Wood L, Disner SG, Dobryakova E, Eapen BC, Edelstein RM, Esopenko C, Genova HM, Geuze E, Goodrich-Hunsaker NJ, Grafman J, Håberg AK, Hodges CB, Hoskinson KR, Hovenden ES, Irimia A, Jahanshad N, Jha RM, Keleher F, Kenney K, Koerte IK, Liebel SW, Livny A, Løvstad M, Martindale SL, Max JE, Mayer AR, Meier TB, Menefee DS, Mohamed AZ, Mondello S, Monti MM, Morey RA, Newcombe V, Newsome MR, Olsen A, Pastorek NJ, Pugh MJ, Razi A, Resch JE, Rowland JA, Russell K, Ryan NP, Scheibel RS, Schmidt AT, Spitz G, Stephens JA, Tal A, Talbert LD, Tartaglia MC, Taylor BA, Thomopoulos SI, Troyanskaya M, Valera EM, van der Horn HJ, Van Horn JD, Verma R, Wade BSC, Walker WC, Ware AL, Werner JK, Yeates KO, Zafonte RD, Zeineh MM, Zielinski B, Thompson PM, Hillary FG, Tate DF, Wilde EA, Dennis EL.   +80 more
europepmc   +1 more source