Results 191 to 200 of about 8,047 (306)

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Examining the Relationship Between Early Feeding Difficulties and Language Development: A Longitudinal Study. [PDF]

Dev Psychobiol
Poulin S, McFarland DH, Rezzonico S, Trudeau N.   +3 more
europepmc   +1 more source

A Pathology‐Instructed Theranostic Platform with Mechanoadaptive and ROS‐Powered Nanobreathing Functions for Precision Myocardial Repair

Advanced Science, EarlyView.
We developed a pH responsive theranostic serum albumin hydrogel named BST, functionalized with MRI and CT probes and loaded with mitochondria targeted CAT‐SOD nanogels, that rapidly self repairs and mechanically stabilizes the infarcted myocardium, releases therapeutic nanogels and albumin under hypoxia induced acidosis to clear mitochondrial ROS ...
Zheng Luo, Cui Yang, Liuzhou Mao, Panqin Ma, Chiyu Jia, Karen Yuanting Tang, Xian Jun Loh, Yun‐Long Wu   +7 more
wiley   +1 more source

Black carbon emissions generally underestimated in the global south as revealed by globally distributed measurements. [PDF]

Nat Commun
Ren Y, Oxford CR, Zhang D, Liu X, Zhu H, Dillner AM, White WH, Chakrabarty RK, Hasheminassab S, Diner DJ, Le Roy EJ, Kumar J, Viteri V, Song K, Akoshile C, Amador-Muñoz O, Asfaw A, Chang RY, Francis D, Gahungu P, Garland RM, Grutter M, Kim J, Langerman K, Lee PC, Lestari P, Mayol-Bracero OL, Naidoo M, Nelli N, O'Neill N, Park SS, Salam A, Sarangi B, Schechner Y, Schofield R, Tripathi SN, Windwer E, Wu MT, Zhang Q, Rudich Y, Brauer M, Martin RV.   +41 more
europepmc   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

Evaluation of the diagnostic capacity for neglected tropical diseases in a refugee settlement in Uganda: a cross-sectional study. [PDF]

Trop Med Health
Tamale E, Malinga PD, Nabweteme MS, Ahurira C, Makai C, Ssembuze KJ, Aketoko PA, Atuhaire P.   +7 more
europepmc   +1 more source

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source

Determining the Protective Effects of Long‐Term Physical Activity, Exercise, Mental Health, and Employment on Sarcopenia—A Result of a Feasibility Study of a Registry

AGING MEDICINE, EarlyView.
This study highlights that physical activity, employment, and mental health significantly influence sarcopenia risk in healthy adults. Working part‐time or full‐time and exercising, especially sports like swimming, alongside good psychological health, may be associated with reduced odds of sarcopenia.
Mohammad Reza Shadmand Foumani Moghadam, Mostafa Shahraki Jazinaki, Sharif Etemadi, Kazem Eslami, Pegah Meghdadi, Parnian Pezeshki, Mohammad Amoushahi, Reyhane Bakhshipour, Majid Ghayour Mobarhan, Majid Khadem‐Rezaiyan, Reza Rezvani, Zohre Hosseini   +11 more
wiley   +1 more source

Smart Denture with Embedded Thin‐Film Temperature Sensors Patterned by Femtosecond Laser Pulse for Elderly Healthcare

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
We demonstrate the direct‐laser patterning of a gold thin film on polymethyl methacrylate to fabricate a temperature sensor for dentures. The temperature sensor‐embedded smart dentures are evaluated in an oral environment, enabling in‐situ monitoring for elderly healthcare.
Han Ku Nam, Yong Kwon Chae, Seoung‐Jin Hong, Younggen Lee, Dongwook Yang, Byunggi Kim, Sang Wook Kang, Young‐Jin Kim   +7 more
wiley   +1 more source

Balancing public health needs and economic sustainability: A dual-matrix model for community pharmacy inventory management. [PDF]

Explor Res Clin Soc Pharm
Jelić AG, Vučenović VT, Vučenović S, Marković-Peković V, Kurdi A, Godman B, Meyer JC, Škrbić R.   +7 more
europepmc   +1 more source