Results 201 to 210 of about 2,359,633 (295)

Multi‐Tissue Crosstalk Regulating Meniscus Healing Under Inflammation and Physiological Loading

Advanced Science, EarlyView.
Using a novel Meniscus‐on‐a‐chip (MoC) model integrated with a meniscus‐specific bioreactor, this study investigated the roles of multi‐tissue crosstalk that regulates injury, healing, and degeneration of the meniscus injury under inflammation and pathophysiological loading.
Hun Jin Jeong, Elen Zhu, Min Seo Kang, Ming Wang, Sam Comito, Chang H. Lee   +5 more
wiley   +1 more source

Neighborhood deadwood and yard rewilding modulate commensal microbiomes and inflammatory signals among urbanites. [PDF]

Microbiome
Roslund MI, Uimonen L, Kummola L, Cerrone D, Ojala A, Luukkonen A, Holopainen E, Korhonen A, Penttilä R, Saarenpää M, Venäläinen M, Haveri H, Rajaniemi J, Laitinen OH, Sinkkonen A, Group TBR.   +15 more
europepmc   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Linking Symptom Inventories Using Semantic Textual Similarity. [PDF]

J Neurotrauma
Kennedy E, Vadlamani S, Lindsey HM, Peterson KS, Dams O'Connor K, Agarwal R, Amiri HH, Andersen RK, Babikian T, Baron DA, Bigler ED, Caeyenberghs K, Delano-Wood L, Disner SG, Dobryakova E, Eapen BC, Edelstein RM, Esopenko C, Genova HM, Geuze E, Goodrich-Hunsaker NJ, Grafman J, Håberg AK, Hodges CB, Hoskinson KR, Hovenden ES, Irimia A, Jahanshad N, Jha RM, Keleher F, Kenney K, Koerte IK, Liebel SW, Livny A, Løvstad M, Martindale SL, Max JE, Mayer AR, Meier TB, Menefee DS, Mohamed AZ, Mondello S, Monti MM, Morey RA, Newcombe V, Newsome MR, Olsen A, Pastorek NJ, Pugh MJ, Razi A, Resch JE, Rowland JA, Russell K, Ryan NP, Scheibel RS, Schmidt AT, Spitz G, Stephens JA, Tal A, Talbert LD, Tartaglia MC, Taylor BA, Thomopoulos SI, Troyanskaya M, Valera EM, van der Horn HJ, Van Horn JD, Verma R, Wade BSC, Walker WC, Ware AL, Werner JK, Yeates KO, Zafonte RD, Zeineh MM, Zielinski B, Thompson PM, Hillary FG, Tate DF, Wilde EA, Dennis EL.   +80 more
europepmc   +1 more source

Nuclear IDH3A Drives Transcriptional Programs in Melanoma via the YBX1–JUN/FOS Axis

Advanced Science, EarlyView.
Genomic amplification drives aberrant nuclear localization of IDH3A in melanoma. Independent of its canonical metabolic activity, nuclear IDH3A cooperates with YBX1 to activate the c‐JUN/c‐FOS transcriptional program, while NONO facilitates its nuclear localization.
Juan Ran, Yanchun Fang, Shengming Ruan, Juling Wang, Songbai Liu, Yuan Mao, Dongsheng Hou, Yanping Wang, Zi Ye, Qiong Li, Daoxiang Zhang   +10 more
wiley   +1 more source

Amazonian Fungal Diversity and the Potential of Basidiomycetes as Sources of Novel Antimicrobials. [PDF]

Biology (Basel)
Dos Santos LCRM, de Almeida JDR, de Sousa NSO, Fernandes FDS, Ennes JFV, Frickmann H, de Souza JVB, de Souza ÉS.   +7 more
europepmc   +1 more source

PLXDC2 siRNA‐Mediated Intervention Attenuates Microglial Senescence Through cGAS‐STING Signaling

Advanced Science, EarlyView.
PLXDC2 was identified as a microglial target in Parkinson's disease through human and mouse single‐cell analyses. Ferritin‐armed biomimetic nanovesicles delivered PLXDC2 siRNA, deferoxamine, and CeO2 nanoparticles across the blood–brain barrier, reducing cGAS‐STING activation, iron burden, oxidative stress, and senescence in microglia, thereby ...
Heyue Lu, Zitian Zheng, Feiran Wang, Huanhuan Luo, Fei Ju, Yucheng Zhu, Zheng Zhou, Jie Sun, Zhenghui Qiu, Xiang Luo, Zhongzheng Jia, Jianquan Wang, Hongjie Huang, Bo Zhang   +13 more
wiley   +1 more source

Detaching Photosensitive Nanoparticles from Cells Prevents Them from Remaining in Cells after Photoporation

Advanced Science, EarlyView.
Phenylboronic acid‐functionalized gold nanoparticles reversibly attach to cell‐surface glycans, enhancing photoporation‐mediated intracellular delivery. After irradiation, ATP competitively disrupts the boronic ester interactions and removes cell‐associated nanoparticles, markedly reducing residual gold.
Tao Lu, Mina Nikolić, Baihao Huang, Deep Punj, Herlinde De Keersmaecker, Thibaut Van Acker, Wenjia Xie, Florian Vanlauwe, Phillip Blondeel, Liesl De Graeve, Félix Sauvage, Ranhua Xiong, Chaobo Huang, Frank Vanhaecke, Kevin Braeckmans, Stefaan C. De Smedt   +15 more
wiley   +1 more source

Estimating facility-level greenhouse gas emissions in U.S. hospitals with machine learning imputation of incomplete self-reported data. [PDF]

Clean Environ Syst
Yin H, Eckel SP, Kaur M, Cohen G, Sutherland L, Tome M, Chen BE, Motamed A, Meshkati N, Hu H, McConnell R, Sharma B.   +11 more
europepmc   +1 more source