Results 61 to 70 of about 121,760 (314)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Perfecţionarea contabilităţii perisabilităţii naturale a stocurilor
Agricultural Science, 2010 Currently there is no single way of accounting for natural perishability inventories of agricultural enterprises. Specialists’ opinions differ. Therefore, in practice there are many uncertainties and risks of confusion that make it complicate for the ...
KIREITEV G. , FRECĂUŢEANU, A.
doaj
Robustness of Online Inventory Balancing to Inventory Shocks
, 2021 <div> <div> In classic adversarial online resource allocation problems, such as matching, AdWords, or assortment planning, customers (demand) arrive online, while products (supply) are given offline with a fixed initial inventory. To ensure acceptable revenue guarantees given the uncertainty in future customer arrivals, the decision ...
Yiding Feng, Rad Niazadeh, Amin Saberi
openaire +3 more sources
Inventories and Optimal Monetary Policy [PDF]
We introduce inventories into a standard New Keynesian Dynamic Stochastic General Equilibrium (DSGE) model to study the effect on the design of optimal monetary policy.
Wing Leong Teo, Thomas A. Lubik
core
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Communications Earth & EnvironmentEstimating accurate oil and gas methane emissions has been a global challenge, highlighted by a twofold discrepancy between atmospheric measurement-based estimates and emission inventories.
Elton Chan +8 more
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Sant och falskt om Gripsholmstavlorna
ICO Iconographisk Post, 2020 The iconography of the lost 16th-century painted wall hangings from Gripsholm Castle, Sweden, has been subject to discussion for more than 300 years.
Herman Bengtsson
doaj