Results 51 to 60 of about 950,178 (298)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

2018 Limited access state numbered highways. 2017: Dec. 31.

, 2017
Annual; Each v. reports data for the previous year; e.g. 1987 v. presents 1986 data.; Issued by: Road Inventory and Records Unit, ; Engineering Data and Inventory Section, -1982; Division of Planning Inventory and Data, 1983-1990; Planning Inventory and ...

core   +1 more source

The Readington Township Natural Resource Inventory

, 2001
The Readington Township Natural Resource Inventory is a comprehensive compilation of text, maps, and tables that fully describe the current environmental resources in the Township. The plan contains an overview of current resource protection information,

core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

OWNERSHIP STRUCTURE AND INVENTORY POLICY [PDF]

This paper explores the effect of a firm’s ownership structure on its inventory policy. We have argued that the presence of institutional investors like banks as blockholders, reduces a firm’s liquidity needs and prevents overinvestment policies.
Josep A. Tribó
core   +2 more sources

Comparative Operational Performance of Baited Logs, Lure Traps, and Flight-Intercept Traps in a Province-Scale Surveillance Program for Pine Wood-Boring Beetles in Yunnan, Southwestern China

Insects
National and provincial surveillance of pine wood-boring pests in China is designed to detect damaging taxa, map occurrence, assess risk and loss, and support early warning, zoning and control decisions.
Jidong Liu, Qi Jiang, Shaoshun He, Zhengqing Wu, Jianrong Wu, Taoyou Ping, Yujie Liu   +6 more
doaj   +1 more source

Rediscovery of Lycodon gammiei (Blanford, 1878) (Serpentes, Colubridae) in Xizang, China, with comments on its systematic position [PDF]

ZooKeys
Lycodon gammiei (Blanford, 1878), a rarely encountered species of Asian snake, is characterized by ambiguous systematics and biology. Based on a sole specimen of L.
Fu Shu, Bing Lyu, Keji Guo, Tong Zhang, Xiaoqi Mi, Li Li, Yayong Wu, Peng Guo   +7 more
doaj   +3 more sources

Inventory of County Records, Collin County Courthouse, McKinney, Texas

, 1976
Annotated inventory of records documenting the history of Collin County, housed in the Collin County Courthouse in McKinney, Texas, including an overview of the county government offices.
Texas County Records Inventory Project
core