Results 71 to 80 of about 978,873 (303)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Characteristics of fume components and dynamic emission behavior of crumb-rubber-modified asphalt

Frontiers in Materials
IntroductionCrumb-rubber-modified asphalt (CRMA) facilitates the recycling of end-of-life tires but may release complex fumes during high-temperature processing. This study characterized the dynamic fume evolution and representative organic components of
Liaoliang Luo, Jiasheng Dai, Wenqiang Zhu, Changfeng Li, Long Yu, Yu Liu, Binqian Li, Zhenghao Zhang   +7 more
doaj   +1 more source

Robustness of Online Inventory Balancing to Inventory Shocks

, 2021
<div> <div> In classic adversarial online resource allocation problems, such as matching, AdWords, or assortment planning, customers (demand) arrive online, while products (supply) are given offline with a fixed initial inventory. To ensure acceptable revenue guarantees given the uncertainty in future customer arrivals, the decision ...
Yiding Feng, Rad Niazadeh, Amin Saberi
openaire   +3 more sources

Evidence of improved inventory control [PDF]

Inventory data applied to a standard partial stock-adjustment model demonstrate that inventory control, defined by desired marginal inventory-sales ratios and speeds of adjustment, improved in the last decade or so, particularly in the manufacturing ...
Dan M. Bechter, Stephen Stanley
core  

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Comparative Operational Performance of Baited Logs, Lure Traps, and Flight-Intercept Traps in a Province-Scale Surveillance Program for Pine Wood-Boring Beetles in Yunnan, Southwestern China

Insects
National and provincial surveillance of pine wood-boring pests in China is designed to detect damaging taxa, map occurrence, assess risk and loss, and support early warning, zoning and control decisions.
Jidong Liu, Qi Jiang, Shaoshun He, Zhengqing Wu, Jianrong Wu, Taoyou Ping, Yujie Liu   +6 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

2020 Limited access state numbered highways. as of 2019: Dec. 31.

, 2020
Annual; Each v. reports data for the previous year; e.g. 1987 v. presents 1986 data.; Issued by: Road Inventory and Records Unit, ; Engineering Data and Inventory Section, -1982; Division of Planning Inventory and Data, 1983-1990; Planning Inventory and ...

core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Rediscovery of Lycodon gammiei (Blanford, 1878) (Serpentes, Colubridae) in Xizang, China, with comments on its systematic position [PDF]

ZooKeys
Lycodon gammiei (Blanford, 1878), a rarely encountered species of Asian snake, is characterized by ambiguous systematics and biology. Based on a sole specimen of L.
Fu Shu, Bing Lyu, Keji Guo, Tong Zhang, Xiaoqi Mi, Li Li, Yayong Wu, Peng Guo   +7 more
doaj   +3 more sources