Results 61 to 70 of about 978,873 (303)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Notulae Scientia Biologicae, 2020 The forest in India have a long history of human induced modifications through intensive forest management that began in the colonial period but continued afterwards to meet the wood-based demand until the forestry goals shifted towards conservation ...
Arun K. THAKUR +2 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Comparative evaluation of funnel, box, and camera traps for reptile and amphibian inventory
Wildlife Society BulletinSpecies inventories provide baseline knowledge to inform land management decisions, especially for cryptic species like reptiles and amphibians. Traditionally, funnel and box traps positioned along drift‐fence arrays have been used to survey herpetofauna.
Tyler B. DeVos +6 more
doaj +1 more source
Ecological Restoration of Limestone Tailings in Arid Regions: A Synergistic Substrate–Plant Approach
BiologyIn arid regions, the ecological restoration of limestone tailings requires sustainable strategies, yet the synergistic effects of substrate optimization and native plant selection remain poorly understood.
Wei Hou +8 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Inventory of County Records, Collin County Courthouse, McKinney, Texas
, 1976 Annotated inventory of records documenting the history of Collin County, housed in the Collin County Courthouse in McKinney, Texas, including an overview of the county government offices.
Texas County Records Inventory Project
core
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source