Results 51 to 60 of about 17,730,527 (305)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

PENINGKATAN KINERJA PERSEDIAAN PRODUK DI PT. PROPAN RAYA I.C.C SURABAYA

Jurnal Ilmiah Teknik Industri, 2013
Inventory control is an internal process that is essential for the company's operations, especially in the field of industrial paints. Many types, colors and sizes of packaging paint often urged companies to hoard supplies.
Yuki Tejo Prakoso, Evi Yuliawati
doaj  

DESARROLLO DE UN SISTEMA DE GESTIÓN DE INVENTARIOS PARA EL CONTROL DE MATERIALES, EQUIPOS Y HERRAMIENTAS DENTRO DE LA EMPRESA DE CONSTRUCCIÓN REALIDAD COLOMBIA S.A.S

Revista Ingeniería, Matemáticas y Ciencias de la Información, 2023
The company Realidad Colombia SAS is dedicated to the contracting and execution of civil works, especially in thedepartment of Risaralda. Currently, it is developing its work in the Terragrata condominium in the city of Dosquebradas,in the process of ...
Santiago Parra Angel, Ever Ángel Fuentes Rojas   +1 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Refinement of the Facility-Level Medical Technology Score to Reflect Key Disease Response Capacity and Personnel Availability

IEEE Journal of Translational Engineering in Health and Medicine, 2013
This paper presents a second look at the computation of the Medical Technology Score (MTS), a metric designed to convey the relative technical competence of a health facility. Modification of the score to reflect local disease burden is discussed, as are
Olumurejiwa A. Fatunde, Timothy W. Kotin
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Multiple–Warehouse Sliding Mode Control with A Predefined Demand Trajectory Profile

International Journal of Applied Mathematics and Computer Science
The paper discusses the inventory management problem with a single product stored in two warehouses, where each has its unique suppliers with certain lead times. Moreover, one of the warehouses may act as a backup supplier for the other.
Adamiak Katarzyna, Zwierzchowski Tymoteusz   +1 more
doaj   +1 more source

Distribution free approach on electrical energy supply chain using geometric shipment policy

International Journal of Sustainable Engineering, 2021
We propose an inventory based optimisation model for a system of electricity supply chain. This distribution system consists of power plant, transmission substation and distribution substations and customers.
S. Hemapriya, R. Uthayakumar
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source