Results 91 to 100 of about 3,077,553 (314)
The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity
FEBS Open Bio, EarlyView.We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda +9 more
wiley +1 more source
Limit cycles in models of circular gene networks regulated by negative feedback loops
BMC Bioinformatics, 2020 Background The regulatory feedback loops that present in structural and functional organization of molecular-genetic systems and the phenomenon of the regulatory signal delay, a time period between the moment of signal reception and its implementation ...
Vitaly A. Likhoshvai +2 more
doaj +1 more source
Applications of inverse simulation to a nonlinear model of an underwater vehicle [PDF]
, 2008 Inverse simulation provides an important alternative to conventional simulation and to more formal mathematical techniques of model inversion. The application of inverse simulation methods to a nonlinear dynamic model of an unmanned underwater ...
Lu, L., McGookin, E., Murray-Smith, D.
core
Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo
FEBS Open Bio, EarlyView.The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu +12 more
wiley +1 more source
Combinatorial Gelfand models for some semigroups and q-rook monoid algebras [PDF]
, 2007 Inspired by the results of [R. Adin, A. Postnikov, Y. Roichman, Combinatorial Gelfand model, preprint math.RT arXiv:0709.3962], we propose combinatorial Gelfand models for semigroup algebras of some finite semigroups, which include the symmetric inverse ...
Kudryavtseva, Ganna +1 more
core +1 more source
FEBS Open Bio, EarlyView.Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr +5 more
wiley +1 more source
On inverse and generalized inverses of Hessenberg matrices
Linear Algebra and its Applications, 1988 New algorithms for computing inverses and generalized inverses of a class of real Hessenberg matrices are given. The simple structure of the inverses and the generalized inverses satisfying one, several or even all of the Penrose equations are established. The method of inverting a block triangular matrix and the proposed algorithms are used to compute
openaire +2 more sources
Structural and functional characterization of chitinase from carnivorous plant Drosera adelae
FEBS Open Bio, EarlyView.A class I chitinase from the carnivorous plant Drosera adelae was expressed and purified using a yeast system, revealing high enzymatic activity. Structural analyses of the catalytic and chitin‐binding domains identified key tyrosine residues involved in substrate binding, offering insights into the enzyme's adaptation for insect digestion.
Kazunari Yoneda +7 more
wiley +1 more source
Time‐Frequency Fingerprint Analysis in SEEG Source‐Space to Identify the Epileptogenic Zone
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT This case study highlights the application of seizure fingerprint analysis in the source‐space of stereo‐EEG (SEEG) data to accurately localize the epileptogenic zone (EZ) in patients with complex cortical malformations. A 25‐year‐old female with extensive bilateral perisylvian polymicrogyria (PMG) presented with intractable focal seizures ...
Yash Shashank Vakilna +10 more
wiley +1 more source