Results 111 to 120 of about 1,336,490 (306)

Inverse vaccines - Friend, Not Foe: How Inverse Vaccines Tackle Autoimmune Diseases [PDF]

open access: yes
Inverse vaccines are a new and exciting approach to treating autoimmune diseases. Unlike traditional vaccines that train the immune system to fight off pathogens, inverse vaccines aim to reprogram the immune system to stop attacking healthy ...
Qiongqiong Angela, Zhou   +1 more
core   +1 more source

Inverse coordination chemistry: A novel chemical concept [PDF]

open access: yes, 2020
Inverse Coordination Chemistry: A Novel Chemical Concept presents the fascinating array of inverse coordination complexes, from monoatomic centres to those with organic molecules as centres, in a systematic manner with full-colour illustrative examples ...
Haiduc, Ionel, Tiekink, Edward R. T. *
core  

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

Statistical inference for inverse problems [PDF]

open access: yes
In this paper we study statistical inference for certain inverse problems. We go beyond mere estimation purposes and review and develop the construction of confidence intervals and confidence bands in some inverse problems, including deconvolution and ...
Bissantz, Nicolai, Holzmann, Hajo
core  

Inverse-Designed Diamond Photonics

open access: yes, 2018
Diamond hosts optically active color centers with great promise in quantum computation, networking, and sensing. Realization of such applications is contingent upon the integration of color centers into photonic circuits. However, current diamond quantum
Daniil M. Lukin (14385306)   +12 more
core   +1 more source

Ultrafast visual detection of Streptococcus suis via HtpsC‐targeted LAMP–CRISPR–Cas12a coupled with lateral flow immunochromatography

open access: yesFEBS Open Bio, EarlyView.
A rapid visual test combines DNA amplification, CRISPR–based target verification, and a lateral flow strip to detect Streptococcus suis. The assay gives results in about 45 min, reduces false‐positive interpretation, and does not require fluorescence equipment.
Liu‐xin Li   +7 more
wiley   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

open access: yesFEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao   +23 more
wiley   +1 more source

Experimental and Computational Modeling of Complex Fluid Dispensing Systems

open access: yesEng
In this work, we present a series of experimental and computational modeling procedures related to precision controls of intermittent dispensing systems for complex fluids.
Sheldon Wang   +5 more
doaj   +1 more source

On Tournament Inversion

open access: yesJournal of Graph Theory
ABSTRACTAn inversion of a tournament is obtained by reversing the direction of all edges with both endpoints in some set of vertices. Let be the minimum length of a sequence of inversions using sets of size at most that result in the transitive tournament. Let be the maximum of taken over ‐vertex tournaments.
openaire   +3 more sources

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub   +24 more
wiley   +1 more source

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