Results 91 to 100 of about 1,336,490 (306)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

A NOVEL PUBLIC-KEY CRYPTOGRAPHY SCHEME UTILIZING SKEW CIRCULANT MATRICES WITH GENERALIZED ALTERNATING FIBONACCI

open access: yesBarekeng
Circulant and skew circulant matrices play a significant role in various applications, especially in cryptography. Their determinants and inverses can be used in the decryption process.
Sapto Mukti Handoyo   +2 more
doaj   +1 more source

Limit cycles in models of circular gene networks regulated by negative feedback loops

open access: yesBMC Bioinformatics, 2020
Background The regulatory feedback loops that present in structural and functional organization of molecular-genetic systems and the phenomenon of the regulatory signal delay, a time period between the moment of signal reception and its implementation ...
Vitaly A. Likhoshvai   +2 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

Generalized modes in Bayesian inverse problems [PDF]

open access: yes, 2019
Uncertainty quantification requires efficient summarization of high- or even infinite-dimensional (i.e., non-parametric) distributions based on, e.g., suitable point estimates (modes) for posterior distributions arising from model-specific prior ...
Piiroinen, Petteri   +3 more
core   +1 more source

Inverse Kinematics without matrix inversion

open access: yes2008 IEEE International Conference on Robotics and Automation, 2008
This paper presents a new singularity robust and computationally efficient method for solving the inverse kinematics (IK) problem. In this method, the transformation from Cartesian space to joint space is performed in a feedback loop and as a result the new feedback inverse kinematics (FIK) law operates as a filter and does not require matrix ...
openaire   +3 more sources

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

open access: yesMolecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba   +5 more
wiley   +1 more source

Presentations of inverse semigroups, their kernels and extensions [PDF]

open access: yes, 2011
"Part of this work was done while Gray was an EPSRC Postdoctoral Research Fellow at the University of St Andrews, Scotland"Let S be an inverse semigroup and let π:S→T be a surjective homomorphism with kernel K.
Ruskuc, Nik   +9 more
core   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

open access: yesMolecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński   +12 more
wiley   +1 more source

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