Results 71 to 80 of about 3,065,012 (270)

Analytic determinants and inverses of Toeplitz and Hankel tridiagonal matrices with perturbed columns

open access: yesSpecial Matrices, 2020
In this paper, our main attention is paid to calculate the determinants and inverses of two types Toeplitz and Hankel tridiagonal matrices with perturbed columns.
Fu Yaru   +3 more
doaj   +1 more source

Distributive inverse semigroups and non-commutative Stone dualities [PDF]

open access: yes, 2013
We develop the theory of distributive inverse semigroups as the analogue of distributive lattices without top element and prove that they are in a duality with those etale groupoids having a spectral space of identities, where our spectral spaces are not
Lawson, Mark V, Lenz, Daniel H
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

Inverses and eigenvalues of diamondalternating sign matrices

open access: yesSpecial Matrices, 2014
An n × n diamond alternating sign matrix (ASM) is a (0, +1, −1)-matrix with ±1 entries alternatingand arranged in a diamond-shaped pattern. The explicit inverse (for n even) or generalized inverse (for nodd) of a diamond ASM is derived.
Catral Minerva   +3 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Limit cycles in models of circular gene networks regulated by negative feedback loops

open access: yesBMC Bioinformatics, 2020
Background The regulatory feedback loops that present in structural and functional organization of molecular-genetic systems and the phenomenon of the regulatory signal delay, a time period between the moment of signal reception and its implementation ...
Vitaly A. Likhoshvai   +2 more
doaj   +1 more source

Uniqueness and Stability in Inverse Spectral Problems for Collapsing Manifolds [PDF]

open access: yes, 2012
We consider a geometric inverse problems associated with interior measurements: Assume that on a closed Riemannian manifold $(M, h)$ we can make measurements of the point values of the heat kernel on some open subset $U \subset M$. Can these measurements
Kurylev, Yaroslav   +2 more
core  

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

open access: yesFEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi   +6 more
wiley   +1 more source

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