Results 81 to 90 of about 3,872,829 (369)

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

open access: yesMolecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach   +8 more
wiley   +1 more source

A Study of Determinants and Inverses for Periodic Tridiagonal Toeplitz Matrices with Perturbed Corners Involving Mersenne Numbers

open access: yesMathematics, 2019
In this paper, we study periodic tridiagonal Toeplitz matrices with perturbed corners. By using some matrix transformations, the Schur complement and matrix decompositions techniques, as well as the Sherman-Morrison-Woodbury formula, we derive explicit ...
Yunlan Wei   +3 more
doaj   +1 more source

Gait Event Prediction Using Surface Electromyography in Parkinsonian Patients

open access: yesBioengineering, 2023
Gait disturbances are common manifestations of Parkinson’s disease (PD), with unmet therapeutic needs. Inertial measurement units (IMUs) are capable of monitoring gait, but they lack neurophysiological information that may be crucial for studying gait ...
Stefan Haufe   +3 more
doaj   +1 more source

A DIA‐MS‐based proteomics approach to find potential serum prognostic biomarkers in glioblastoma patients

open access: yesMolecular Oncology, EarlyView.
A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul   +11 more
wiley   +1 more source

Discovery of New Ti-Based Alloys Aimed at Avoiding/Minimizing Formation of α” and ω-Phase Using CALPHAD and Artificial Intelligence

open access: yesMetals, 2020
In this work, we studied a Ti-Nb-Zr-Sn system for exploring novel composition and temperatures that will be helpful in maximizing the stability of β phase while minimizing the formation of α” and ω-phase. The Ti-Nb-Zr-Sn system is free of toxic elements.
Rajesh Jha, George S. Dulikravich
doaj   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

open access: yesFEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli   +15 more
wiley   +1 more source

Resistance Distance in the Double Corona Based on R-Graph

open access: yesMathematics, 2019
Let G 0 be a connected graph on n vertices and m edges. The R-graph R ( G 0 ) of G 0 is a graph obtained from G 0 by adding a new vertex corresponding to each edge of G 0 and by joining each new vertex to the end
Li Zhang   +3 more
doaj   +1 more source

Prediction of Protein Tertiary Structure via Regularized Template Classification Techniques

open access: yesMolecules, 2020
We discuss the use of the regularized linear discriminant analysis (LDA) as a model reduction technique combined with particle swarm optimization (PSO) in protein tertiary structure prediction, followed by structure refinement based on singular value ...
Óscar Álvarez-Machancoses   +2 more
doaj   +1 more source

Inverse Density as an Inverse Problem: The Fredholm Equation Approach [PDF]

open access: yes, 2013
In this paper we address the problem of estimating the ratio $\frac{q}{p}$ where $p$ is a density function and $q$ is another density, or, more generally an arbitrary function.
Belkin, Mikhail, Que, Qichao
core  

Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification

open access: yesFEBS Open Bio, EarlyView.
Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski   +13 more
wiley   +1 more source

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