Results 71 to 80 of about 1,391,068 (260)

Inverse Design of Incoherent Raman Pump Sources for U-Band WDM Transmission Over 125 km G.652.D Fiber

IEEE Photonics Journal
The ever-increasing demand for the transmission capacity has stimulated intensive investigations, in terms of both new transmission window of standard single mode fiber (SSMF) and new fiber utilizing the spatial domain.
Tangyanjun Lan, Junjiang Xiang, Gai Zhou, Meng Xiang, Songnian Fu, Yuwen Qin   +5 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Estimating Nuisance Parameters in Inverse Problems

, 2012
Many inverse problems include nuisance parameters which, while not of direct interest, are required to recover primary parameters. Structure present in these problems allows efficient optimization strategies - a well known example is variable projection,
Aleksandr Y Aravkin, Aravkin A Y, Aravkin A Y Styer M Moratto Z Nefian A Broxton M, Bunks C, Fahrmeir L, Golub G H, Horesh L, Lange K L, Nelder J A, Osborne M R, Petersen K B, Rockafellar R T, Schmidt M Van Den Berg E Friedlander M P Murphy K, Seber G A F, Tarantola A, Tarantola A, Tristan van Leeuwen, Venables W N   +17 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Protein design in a lattice model of hydrophobic and polar amino acids

, 1997
A general strategy is described for finding which amino acid sequences have native states in a desired conformation (inverse design). The approach is used to design sequences of 48 hydrophobic and polar aminoacids on three-dimensional lattice structures.
A. Lombardi, A. Sali, Amos Maritan, C. J. Camacho, C. Pabo, Cristian Micheletti, E. I. Shakhnovich, E. I. Shakhnovich, F. Seno, Flavio Seno, H. Li, H. S. Chan, J. Bryngelson, J. M. Deutsch, J. N. Onuchic, J. U. Bowie, J. W. Ponder, Jayanth R. Banavar, K. A. Dill, K. F. Lau, K. F. Lau, K. Yue, K. Yue, K. Yue, K. Yue, M. H. J. Cordes, M. P. Morrissey, S. J. Sun, S. Kamtekar, T. P. Quinn, Y. Kuroda   +30 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Inverse design of discrete mechanical metamaterials [PDF]

Physical Review Materials, 2019
Mechanical and phononic metamaterials exhibiting negative elastic moduli, gapped vibrational spectra, or topologically protected modes enable precise control of structural and acoustic functionalities. While much progress has been made in their experimental and theoretical characterization, the inverse design of mechanical metamaterials with ...
Ronellenfitsch, H, Stoop, N, Yu, J, Forrow, A, Dunkel, J   +4 more
openaire   +2 more sources

Motion Planning of Uncertain Ordinary Differential Equation Systems [PDF]

, 2011
This work presents a novel motion planning framework, rooted in nonlinear programming theory, that treats uncertain fully and under-actuated dynamical systems described by ordinary differential equations.
Hays, Joe, Hong, Dennis, Sandu, Adrian, Sandu, Corina   +3 more
core   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Physics-agnostic inverse design using transfer matrices

APL Machine Learning
Inverse design is an application of machine learning to device design, giving the computer maximal latitude in generating novel structures, learning from their performance, and optimizing them to suit the designer’s needs.
Nathaniel Morrison, Shuaiwei Pan, Eric Y. Ma   +2 more
doaj   +1 more source